机构：[a]Department of Plastic and Cosmetic Surgery, The Second Affiliated Hospital of Soochow University, Soochow 215004, China[b]Department of Dermatology, The Affiliated Hospital of Nantong University, Nantong 226001, China
The molecular mechanism of the pathogenesis of keloids is still not known and the clinical management of keloids remains challenging. MiRNA (microRNA) is a novel class of small regulatory RNAs that has emerged as key post-transcriptional regulators of gene expression. MiRNAs participate in diverse biological processes of various skin diseases and function as key regulators in the occurrence and development of tumors. The purpose of this study was to investigate the involvement of miRNAs in keloid pathogenesis. We performed miRNA microarray analysis to compare miRNA expression between keloid and normal skin samples. We found that 46 miRNAs were upregulated and 28 miRNAs were down regulated in keloid compared with normal skin samples. We focused on miR-1224-5p, which has been reported to function in cancers, although the expression and mechanism of miR-1224-5p in keloids remain to be explored. Overexpression of miR-1224-5p led to inhibition of keloid fibroblast proliferation, promotion of apoptosis and decrease of migration and invasion. Our results suggest that downregulation of miR-1224-5p may be one of the mechanisms involved in the occurrence and development of keloids. (C) 2017 Elsevier Inc. All rights reserved.
基金：
This researchwas supported by grants from the National Natural
Science Foundation of China (No. 81041076).
第一作者机构：[a]Department of Plastic and Cosmetic Surgery, The Second Affiliated Hospital of Soochow University, Soochow 215004, China[b]Department of Dermatology, The Affiliated Hospital of Nantong University, Nantong 226001, China
通讯作者：
通讯机构：[a]Department of Plastic and Cosmetic Surgery, The Second Affiliated Hospital of Soochow University, Soochow 215004, China[b]Department of Dermatology, The Affiliated Hospital of Nantong University, Nantong 226001, China
推荐引用方式(GB/T 7714)：
Xiaodong Yao,Xiaomei Cui,Xiaoyan Wu,et al.Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-beta 1/Smad3 signaling pathway[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,495(1):713-720.doi:10.1016/j.bbrc.2017.10.070.
APA：
Xiaodong Yao,Xiaomei Cui,Xiaoyan Wu,Pan Xu,Wenyan Zhu...&Tianlan Zhao.(2018).Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-beta 1/Smad3 signaling pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,495,(1)
MLA：
Xiaodong Yao,et al."Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-beta 1/Smad3 signaling pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 495..1(2018):713-720
