Efficacy of long-term nonsteroidal antiinflammatory drug treatment on magnetic resonance imaging-determined bone marrow oedema in early, active axial spondyloarthritis patients
机构：[1]Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Epidemiology and Medical Statistics, School of Public Health, Medical College of Soochow University, Suzhou, China[3]Department of Hematology, the Second Affiliated Hospital of Soochow University, Suzhou, China[4]the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu 215000, People’s Republic of China
To assess the efficacy of long-term treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on bone marrow oedema (BMO) of the sacroiliac joint in newly diagnosed axial spondyloarthritis (SpA) with a symptom duration of less than 4 years, a single-center, open-label study in a cohort of consecutive patients with newly diagnosed axial SpA was conducted. Eligible patients had magnetic resonance imaging (MRI)-determined BMO of the sacroiliac joint at baseline, had a symptom duration of less than 4 years, and were na < ve to NSAIDs. After the baseline MRI, an optimal dose of NSAID was administered for 24 or 48 weeks. BMO of sacroiliac joint was quantified by applying the Spondyloarthritis Research Consortium of Canada (SPARCC) system. Disease activity was expressed using the Ankylosing Spondylitis Disease Activity Score (ASDAS). Primary end points were improvement in BMO of sacroiliac joint at week 24 or week 48. Forty-three patients were recruited, and 33 patients eventually completed the study, including 10 patients having follow-up MRI at week 24 and 23 patients having follow-up MRI at week 48. Overall, the mean of SPARCC score decreased from 21.8 +/- 16.1 at baseline to 10.2 +/- 12.8 at follow-up (p < 0.001). 75.8% of the patients displayed a minimally important change, and 30.3% became free of BMO. The mean of ASDAS-CRP decreased from 3.1 +/- 1.0 at baseline to 2.1 +/- 1.0 at follow-up (p < 0.001). Long-term treatment with optimal dose NSAIDs could significantly alleviate BMO of sacroiliac joint in early and active axial SpA.
第一作者机构：[1]Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Rheumatology and Immunology, the Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Hematology, the Second Affiliated Hospital of Soochow University, Suzhou, China[4]the Second Affiliated Hospital of Soochow University, Sanxiang Road No.1055, Suzhou, Jiangsu 215000, People’s Republic of China
推荐引用方式(GB/T 7714)：
Mei Tang,Leixi Xue,Yueping Shen,et al.Efficacy of long-term nonsteroidal antiinflammatory drug treatment on magnetic resonance imaging-determined bone marrow oedema in early, active axial spondyloarthritis patients[J].CLINICAL RHEUMATOLOGY.2018,37(1):245-250.doi:10.1007/s10067-017-3666-x.
APA：
Mei Tang,Leixi Xue,Yueping Shen,Lin Bo,Ru Yang...&Jinxiang Fu.(2018).Efficacy of long-term nonsteroidal antiinflammatory drug treatment on magnetic resonance imaging-determined bone marrow oedema in early, active axial spondyloarthritis patients.CLINICAL RHEUMATOLOGY,37,(1)
MLA：
Mei Tang,et al."Efficacy of long-term nonsteroidal antiinflammatory drug treatment on magnetic resonance imaging-determined bone marrow oedema in early, active axial spondyloarthritis patients".CLINICAL RHEUMATOLOGY 37..1(2018):245-250
