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Dosimetric comparison of the helical tomotherapy, volumetricmodulated arc therapy and fixed-field intensity-modulated radiotherapy for stage IIB-IIIB nonsmall cell lung cancer

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机构: [1]Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China. [2]Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China. [3]Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, USA. [4]Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou, China
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The study aimed to compare the dosimetric parameters to target dose coverage and the critical structures in the treatment planning of helical tomotherapy (TOMO), volumetric-modulated arc therapy (VMAT), and fixed-field intensity-modulated radiotherapy (IMRT) for NSCLC delivering conventionally fractionated radiotherapy. Thirty patients with pathologically confirmed NSCLC were included. Three radiation treatment plans were designed for each patient. All patients received the uniform prescription dose of 60 Gy to the planning target volume. The conformity index (CI), heterogeneity index (HI), and parameters of critical structures were calculated. A significantly superior mean CI was observed in VMAT than in TOMO or IMRT (P = 0.013, 0.001). Mean HI was also better using VAMT or IMRT than TOMO (P = 0.002, 0.003). Mean lung V-20 and V-30 were significantly reduced by TOMO compared to IMRT (P = 0.019, 0.029). The heart was spared by IMRT compared to TOMO in terms of mean heart dose, V-5, V-10, and V-20 (P < 0.05). In larger tumor, VMAT provided the optimal dose distribution and sparing to heart. Compared to TOMO and IMRT, VMAT achieved better target dose distribution and similar sparing of critical structures. VMAT seemed to be the optimal technique for NSCLC.

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出版当年[2016]版:
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2023]版:
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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出版当年[2015]版:
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版:
Q1 MULTIDISCIPLINARY SCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者:
第一作者机构: [1]Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China. [2]Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
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通讯机构: [1]Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China. [2]Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
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