机构：[1]Department of Orthopaedic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.[2]Department of Anesthesiology, Suzhou BenQ Medical Center, Nanjing Medical University, Suzhou 215009, China.
Background: The purpose of this study was to investigate the therapeutic effects and mechanisms of hyperbaric oxygen (HBO) treatment on rats following spinal cord injury (SCI). Methods: A total of 45 Sprague-Dawley (SD) rats were randomly divided into three groups. Sham-SCI group was surgically exposed but not subjected to the SCI procedure. SCI-control group was administered SCI and treated with regular air. SCI-HBO group was administered SCI and HBO treatment. Neuromotor functions were examined using the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and the inclined plane assessment at before SCI (baseline) and after SCI. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured. Results: Starting from Day 1 after SCI but except Day 2, the SCI-HBO group has significantly higher BBB scores than the SCI-control group. After SCI, the maximum inclination angles at which rats could maintain were significantly lower in both SCI groups. But the maximum angles were significantly bigger for the rats in the SCI-HBO group than those on the SCI-control group at 5, 10 and 20 days after SCI. SOD activities in SCI-HBO rats were significantly higher and MDA levels were significantly lower than in SCI-control rats, at two and five days after SCI. There was also less cystic degeneration of spinal cord in SCI-HBO rats, compared to SCI-control rats. Conclusions: These results suggest that HBO treatment has a therapeutic value in treating SCI. Increased oxygen free radical scavenging and reduced lipid oxidation may be one of the mechanisms.
基金：
This work was supported by an Outstanding Medical Professional Award from the
Suzhou City Government (Suzhou, China) (no:RC0802) and by the “333” project of
Jiangsu province (Jiangsu, China) (no:BRA2011047).
第一作者机构：[1]Department of Orthopaedic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
通讯作者：
通讯机构：[2]Department of Anesthesiology, Suzhou BenQ Medical Center, Nanjing Medical University, Suzhou 215009, China.
推荐引用方式(GB/T 7714)：
Yongming Sun,Dong Liu,Qingpeng Wang,et al.Hyperbaric oxygen treatment of spinal cord injury in rat model[J].BMC NEUROLOGY.2017,17(1):128.doi:10.1186/s12883-017-0909-z.
APA：
Yongming Sun,Dong Liu,Qingpeng Wang,Peng Su&Qifeng Tang.(2017).Hyperbaric oxygen treatment of spinal cord injury in rat model.BMC NEUROLOGY,17,(1)
MLA：
Yongming Sun,et al."Hyperbaric oxygen treatment of spinal cord injury in rat model".BMC NEUROLOGY 17..1(2017):128
