机构：[1]Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.[2]Department of Orthopedics, Second Affiliated Hospital of Soochow University, Suzhou, China.[3]Department of Biological Sciences, Hampton University, Hampton, Virginia.
We evaluated recently published articles relevant to the biological effects of titanium dioxide (TiO2) particles on local endogenous cells required for normal bone homeostasis, repair, and implant osseointegration. Structural characteristics, size, stability, and agglomeration of TiO2 particles alter the viability and behavior of multiple bone-related cell types. Resulting shifts in bone homeostasis may increase bone resorption and lead to clinical incidents of osteolysis, implant loosening, and joint pain. TiO2 particles that enter cells (through endocytosis or Trojan horse mechanism) may further disrupt implant retention. We propose that cellular responses to titanium-based nanoparticles contribute to pathological mechanisms underlying the aseptic loosening of titanium-based metal implants.
基金：
This work was supported by the National Institute of
Arthritis and Musculoskeletal and Skin Diseases of
the National Institutes of Health under award numbers
R01 AR049069 (to A.J.v.W) and F32 AR068154 (to
E.A.L.). We also
thank the Mayo Clinic Center for Regenerative Medicine
Training and Career Development Award (to
R.T.), and the generous philanthropic support from
the William H. and Karen J. Eby Foundation.
语种：
外文
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905,
推荐引用方式(GB/T 7714)：
Jie J. Yao ,Eric A. Lewallen ,William H. Trousdale ,et al.Local Cellular Responses to Titanium Dioxide from Orthopedic Implants[J].BIORESEARCH OPEN ACCESS.2017,6(1):94-103.doi:10.1089/biores.2017.0017.
APA：
Jie J. Yao,,Eric A. Lewallen,,William H. Trousdale,,Wei Xu,,Roman Thaler,...&Andre J. van Wijnen.(2017).Local Cellular Responses to Titanium Dioxide from Orthopedic Implants.BIORESEARCH OPEN ACCESS,6,(1)
MLA：
Jie J. Yao,,et al."Local Cellular Responses to Titanium Dioxide from Orthopedic Implants".BIORESEARCH OPEN ACCESS 6..1(2017):94-103
