机构：[1]Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China[2]Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China[3]Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China
Background: Both Parkinson's disease (PD) and multiple system atrophy (MSA) have associated sleep disorders related to the underlying neurodegenerative pathology. Clinically, MSA with predominant parkinsonism (MSA-P) resembles PD in the manifestation of prominent parkinsonism. Whether the amount of rapid eye movement (REM) sleep without atonia could be a potential marker for differentiating MSA-P from PD has not been thoroughly investigated. This study aimed to examine whether sleep parameters could provide a method for differentiating MSA-P from PD. Methods: This study comprised 24 MSA-P patients and 30 PD patients, and they were of similar age, gender, and REM sleep behavior disorder (RBD) prevalence. All patients underwent clinical evaluation and one night of video-polysomnography recording. The tonic and phasic chin electromyogram (EMG) activity was manually quantified during REM sleep of each patient. We divided both groups in terms of whether they had RBD to make subgroup analysis. Results: No significant difference between MSA-P group and PD group had been found in clinical characteristics and sleep architecture. However, MSA-P patients had higher apnea-hypopnea index (AHI; 1.15 [0.00, 8.73]/h vs. 0.00 [0.00, 0.55]/h, P = 0.024) and higher tonic chin EMG density (34.02 [18.48,57.18]% vs. 8.40 [3.11, 13.06]%, P < 0.001) as compared to PD patients. Subgroup analysis found that tonic EMG density in MSA+RBD subgroup was higher than that in PD+RBD subgroup (55.04 [26.81, 69.62]% vs. 11.40 [8.51, 20.41]%, P < 0.001). Furthermore, no evidence of any difference in tonic EMG density emerged between PD + RBD and MSA - RBD subgroups (P > 0.05). Both disease duration (P = 0.056) and AHI (P = 0.051) showed no significant differences during subgroup analysis although there was a trend toward longer disease duration in PD + RBD subgroup and higher AHI in MSA -RBD subgroup. Stepwise multiple linear regression analysis identified the presence of MSA-P (beta=0.552, P < 0.001) and RBD (beta=0.433, P < 0.001) as predictors of higher tonic EMG density. Conclusion: Tonic chin EMG density could be a potential marker for differentiating MSA-P from PD.
基金：
This study was supported by grants from Jiangsu Provincial
Special Program of Medical Science (No. BL2014042),
Suzhou Clinical Research Center of Neurological
Disease (No. Szzx201503), and Suzhou Clinical Key
Disease Diagnosis and Treatment Technology Foundation
(No. LCZX201304), and was also partly supported by the
Priority Academic Program Development of Jiangsu Higher
Education Institutions (PAPD).
第一作者机构：[1]Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China[2]Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
通讯作者：
通讯机构：[*1]Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu 215004, China
推荐引用方式(GB/T 7714)：
Yi Wang,Yun Shen,Kang-Ping Xiong,et al.Tonic Electromyogram Density in Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease[J].CHINESE MEDICAL JOURNAL.2017,130(6):684-690.doi:10.4103/0366-6999.201603.
APA：
Yi Wang,Yun Shen,Kang-Ping Xiong,Pei-Cheng He,Cheng-Jie Mao...&Chun-Feng Liu.(2017).Tonic Electromyogram Density in Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease.CHINESE MEDICAL JOURNAL,130,(6)
MLA：
Yi Wang,et al."Tonic Electromyogram Density in Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease".CHINESE MEDICAL JOURNAL 130..6(2017):684-690
