机构：[a]Department of Vascular Surgery, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province, P.R. China[b]Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang Province, P.R. China
Angiogenesis is a physiological procedure during which the new blood vessels develop from the pre-existing vessels. Uncontrolled angiogenesis is related to various diseases including cancers. Clinical inhibition of undesired angiogenesis is still under investigation. We utilized nicotinic acid, a family member of the B-vitamin niacin (vitamin B3) that has been used in the prevention and treatment of atherosclerosis or other lipid-metabolic disorders, to treat human umbilical vein endothelial cells (HUVECs) and chick chorioallantoic membrane (CAM), and investigated its influence on angiogenesis in vitro and in vivo. We found that nicotinic acid could obviously inhibit HUVEC proliferation induced by vascular endothelial growth factor. Both the in vitro and in vivo assays showed that nicotinic acid could significantly inhibit the process of angiogenesis. To further investigate the mechanism underlying the effect of nicotinic acid on angiogenesis, we found that it might function via regulating the cytoskeleton arrangements, especially the rearranging the structures of F-actin and paxillin. In summary, we discovered that nicotinic acid could obviously inhibit the process of angiogenesis by changing the angiogenesis factor expression levels and inducing the cytoskeleton rearrangement of endothelial cells.
基金：
This study was supported by a grant from
Natural Science Foundation of Zhejiang Province
of China (LY16H160048).
第一作者机构：[a]Department of Vascular Surgery, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu Province, P.R. China[b]Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang Province, P.R. China
通讯作者：
通讯机构：[*]The Second Affiliated Hospital of Suzhou University, No. 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, P.R. China.
推荐引用方式(GB/T 7714)：
Lemen Pan ,Guanfeng Yu ,Xiangjian Chen ,et al.Nicotinic acid inhibits angiogenesis likely through cytoskeleton remodeling[J].ORGANOGENESIS.2017,13(4):183-191.doi:10.1080/15476278.2017.1364829.
