Significant reduction of peripheral blood interlieukin-35 and CD4(+)EBI3(+) T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients
机构：[1]Department of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China[2]Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Introduction: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4(+)EBI3(+) T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease. Material and methods: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4(+)EBI3(+) T cells in 40 VMC patients and in 20 healthy individuals. Moreover, the plasma IL-17 levels in the VMC patients and in the healthy individuals were detected using an ELISA, and the cardiac Troponin-I (cTnI) levels were detected using a chemiluminescent microparticle immunoassay to compare the differences in the groups. Results: Plasma IL-35 level and the percentage of CD4(+)EBI3(+) T cells in acute phase VMC patients was lower than that in the healthy control group and the convalescent phase VMC patients. Additionally, the plasma IL-35 level in the VMC patients exhibited a negative correlation with the levels of cTnI and IL-17. The percentage of CD4(+)EBI3(+) T cells also showed a negative correlation with the levels of cTnI and IL-17. Conclusions: The plasma IL-35 level and the percentage of CD4(+)EBI3(+) T cells in VMC patients was reduced and the amount of the decrease was associated with the severity of the disease. These results suggest that IL-35 and CD4(+)EBI3(+) T might play important roles in the progression of VMC and could be used as indictors of the disease.
基金：
This study was partly supported by the National Natural
Science Foundation of China (grant no. 81302584,
grant no. 81200507) and the Natural Science Foundation
of Jiangsu Province (grant no. SBK201121707).
第一作者机构：[1]Department of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
通讯作者：
通讯机构：[*1]Department of Cardiology, The Second Affiliated Hospital of Soochow University, 1055 San-Xiang Road, Suzhou, Jiangsu 215004, P.R. China[*2]Department of Nephrology, The Second Affiliated Hospital of Soochow University, 1055 San-Xiang Road, Suzhou, Jiangsu 215004, P.R. China
推荐引用方式(GB/T 7714)：
Han Ouyang,Li Xiang,Jianchang Chen,et al.Significant reduction of peripheral blood interlieukin-35 and CD4(+)EBI3(+) T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients[J].CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY.2017,42(1):91-96.doi:10.5114/ceji.2016.65892.
APA：
Han Ouyang,Li Xiang,Jianchang Chen,Weiting Xu,Yang Jiao&Huaying Shen.(2017).Significant reduction of peripheral blood interlieukin-35 and CD4(+)EBI3(+) T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients.CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY,42,(1)
MLA：
Han Ouyang,et al."Significant reduction of peripheral blood interlieukin-35 and CD4(+)EBI3(+) T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients".CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY 42..1(2017):91-96
