机构：[1]School for Radiological & Interdisciplinary sciences (RAD-X) and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123 Jiangsu, China[2]Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123 Jiangsu, China[3]The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China
A novel ultrasensitive redox-responsive system for the controlled release of doxorubicin (DOX) was fabricated by ditelluride-containing poly(ether-urethane) copolymers. In this study, the ditelluride group was introduced for the first time into water-soluble copolymers used for drug delivery. Doxorubicin loaded in the copolymer nanoparticles can be released in a controlled manner through the cleavage of ditelluride bonds by glutathione (GSH). The ditelluride-containing poly(ether-urethane) nanoparticles were demonstrated to be biocompatible as drug delivery vehicles, therefore opening a new avenue in drug delivery systems for chemotherapy. Furthermore, the in vitro and in vivo studies revealed that the DOX-loaded ditelluride-containing poly(ether-urethane) nanoparticles exhibited efficient uptake in cancer cells, specific tumor targeting and antitumor activity, indicating their excellent potential as novel nanocarriers for drug delivery and cancer therapy.
基金：
This work was supported by a project funded by the National
Natural Science Foundation of China (51503139, 21505096,
and 81401511), Postdoctoral Research Program of Jiangsu
Province (1401062C and 1402109C), Postdoctoral Science
Foundation of China (2014M560442, 2015M571795, and
2015T80575), Natural Science Foundation of the Jiangsu
Higher Education Institutions of China (15KJB150025 and
16KJB320009), the Priority Academic Program Development
of Jiangsu Higher Education Institutions (PAPD), and Jiangsu
Provincial Key Laboratory of Radiation Medicine and
Protection.
第一作者机构：[2]Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123 Jiangsu, China[3]The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China
共同第一作者：
通讯作者：
通讯机构：[1]School for Radiological & Interdisciplinary sciences (RAD-X) and School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123 Jiangsu, China[2]Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123 Jiangsu, China[3]The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004 Jiangsu, China
推荐引用方式(GB/T 7714)：
Yangyun Wang,Lina Zhu,Yong Wang,et al.Ultrasensitive GSH-Responsive Ditelluride-Containing Poly(ether-urethane) Nanoparticles for Controlled Drug Release[J].ACS APPLIED MATERIALS & INTERFACES.2016,8(51):35106-35113.doi:10.1021/acsami.6b14639.
APA：
Yangyun Wang,Lina Zhu,Yong Wang,Liubing Li,Yufeng Lu...&Leshuai W. Zhang.(2016).Ultrasensitive GSH-Responsive Ditelluride-Containing Poly(ether-urethane) Nanoparticles for Controlled Drug Release.ACS APPLIED MATERIALS & INTERFACES,8,(51)
MLA：
Yangyun Wang,et al."Ultrasensitive GSH-Responsive Ditelluride-Containing Poly(ether-urethane) Nanoparticles for Controlled Drug Release".ACS APPLIED MATERIALS & INTERFACES 8..51(2016):35106-35113
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