机构：[1]Department of Radiotherapy and Oncology, Kunshan First People’s Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China[2]Department of Orthopedics, the Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, China
Recent studies have investigated the potential prognostic value of the transmembrane protease serine 4 (TMPRSS4) in various solid tumors. Yet, the results are inconclusive. Here, we performed this meta-analysis to clarify this issue. Relevant articles were identified by searching PubMed, Web of Science and Embase databases. The primary outcome endpoints were patients' overall survival (OS) and time to tumor progression (TTP). Twelve studies involving 1,955 participants were included. We showed that high TMPRSS4 expression in tumor tissues was significantly associated with patients' poor OS (pooled HR = 2.981, 95% CI = 2.296-3.869, P < 0.001) and short TTP (pooled HR = 2.456, 95% CI = 1.744-3.458, P < 0.001). A subgroup analysis revealed that the association between TMPRSS4 and the outcome endpoints (OS or TTP) was also significant within China region. We conclude that TMPRSS4 overexpression in solid tumors is associated with patients' poor prognosis. TMPRSS4 could be a valuable prognosis biomarker or a promising therapeutic target of solid tumor.
基金：
This work is supported by the National Natural Science Foundation (81472786), The Six Talents Peak Project of Jiangsu Province (2012-WSN-012). Kunshan Science and Technology Program (KS1418, KS1528).
第一作者机构：[1]Department of Radiotherapy and Oncology, Kunshan First People’s Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiotherapy and Oncology, Kunshan First People’s Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Zeng Ping,Zhang Peng,Zhou Li-Na,et al.TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis[J].ONCOTARGET.2016,7(46):76327-76336.doi:10.18632/oncotarget.10153.
APA：
Zeng, Ping,Zhang, Peng,Zhou, Li-Na,Tang, Min,Shen, Yi-Xin...&Chen, Min-Bin.(2016).TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis.ONCOTARGET,7,(46)
MLA：
Zeng, Ping,et al."TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis".ONCOTARGET 7..46(2016):76327-76336
医学