机构：[1]Department of Emergency, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi Province, China[2]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
The presence of a salvageable penumbra, a region of ischemic brain tissue with sufficient energy for short-term survival, has been widely agreed as the premise for thrombolytic therapy with tissue plasminogen activator (tPA), which remains the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. However, the use of tPA has been profoundly constrained due to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic transformation (HT). Blood brain barrier (BBB) damage within the thrombolytic time window is an indicator for tPA-induced HT and both normobaric hyperoxia (NBO) and hypothermia have been shown to protect the BBB from ischemia/reperfusion injury. Therefore, providing the O-2 as soon as possible (NBO treatment), freezing the brain (hypothermia treatment) to slow down ischemia-induced BBB damage or their combined use may extend the time window for the treatment of tPA. In this review, we summarize the protective effects of NBO, hypothermia or their use combined with tPA on ischemia stroke, based on which, the combination of NBO and hypothermia may be an ideal early stroke treatment to preserve the ischemic penumbra. Given this, there is an urge for large randomized controlled trials to address the effect.
基金：
This work was supported by Soochow University Research Startup Funds to JX (Q 421500113) and the Priority Academic
Program Development of Jiangsu Higher Education Institutions of China.
语种：
外文
被引次数：
WOS：
PubmedID：
第一作者：
第一作者机构：[1]Department of Emergency, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi Province, China
通讯作者：
通讯机构：[2]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Wen-cao Liu,Xin-chun Jin.Oxygen or cooling, to make a decision after acute ischemia stroke[J].MEDICAL GAS RESEARCH.2016,6(4):206-211.doi:10.4103/2045-9912.196902.
APA：
Wen-cao Liu&Xin-chun Jin.(2016).Oxygen or cooling, to make a decision after acute ischemia stroke.MEDICAL GAS RESEARCH,6,(4)
MLA：
Wen-cao Liu,et al."Oxygen or cooling, to make a decision after acute ischemia stroke".MEDICAL GAS RESEARCH 6..4(2016):206-211
