机构：[1]Department of Urology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China[2]Department of Pathology, Wuxi Hospital of Traditional Chinese Medicine, Wuxi, China[3]Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China[4]Department of Urology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, China[5]Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA[6]Department of Molecular Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA[7]Department of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
ELL-associated factor 2 (EAF2) is an androgen-regulated tumor suppressor in the prostate. The purpose of this study was to investigate the expression of EAF2 protein in human prostate cancer specimens along with BPH specimens as a control, and to evaluate potential association of EAF2 expression with clinical characteristics and overall survival of the prostate cancer patients. The expression of EAF2 was evaluated in 44 prostate cancer and 23 BPH tissue specimens using immunohistochemistry. The relationships of EAF2 expression with clinical characteristics and overall survival rates were analyzed by Chi-square test and Kaplan-Meier method. The immunostaining intensity of EAF2 in BPH specimens was significantly higher than that in prostate cancer (p < 0.05). EAF2 expression decreased significantly in high-grade and advanced-stage human prostate tumors and inversely correlated with PSA level, Gleason scores, bone metastasis and tumor stage. Importantly, loss of EAF2 expression was associated with a significant decrease in patient survival. Expression of EAF2 is decreased in prostate carcinogenesis, and EAF2 loss is associated with high-risk patients and poor survival.
基金：
This work was supported in part
by NIH R01 CA186780 to Z. W., Suzhou social development fund
(SYSD2013089) to Y. Z. and the Priority Academic Program Development
of Jiangsu Higher Education Institutions.
第一作者机构：[1]Department of Urology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China
通讯作者：
通讯机构：[1]Department of Urology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China
推荐引用方式(GB/T 7714)：
Zang Yachen,Dong Yun,Yang Dongrong,et al.Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer[J].INTERNATIONAL UROLOGY AND NEPHROLOGY.2016,48(5):695-700.doi:10.1007/s11255-015-1210-y.
APA：
Zang, Yachen,Dong, Yun,Yang, Dongrong,Xue, Boxin,Li, Feng...&Shan, Yuxi.(2016).Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer.INTERNATIONAL UROLOGY AND NEPHROLOGY,48,(5)
MLA：
Zang, Yachen,et al."Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer".INTERNATIONAL UROLOGY AND NEPHROLOGY 48..5(2016):695-700
