机构:[a]Department of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China[b]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA[c]Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The bla(NDM-1)-harboring plasmids carry IncA/C-2 and IncR replicons, showing a mosaic plasmid structure, and the bla(NDM-1) is harbored on a novel class I integron-like element. bla(KPC-3) is located on a Tn3-Delta bla(TEM-1)-bla(KPC-3)-Delta Tn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.
基金:
This study was supported by National Institutes of Health Grants
R01AI090155 and R21AI117338 and National Natural Science Foundation
of China grant 81572032.
第一作者机构:[a]Department of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China[b]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
共同第一作者:
通讯作者:
通讯机构:[a]Department of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China[b]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
推荐引用方式(GB/T 7714):
Hong Du,Liang Chen,Kalyan D. Chavda,et al.Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases[J].ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.2016,60(4):2519-23.doi:10.1128/AAC.03053-15.
APA:
Hong Du,Liang Chen,Kalyan D. Chavda,Ruchi Pandey,Haifang Zhang...&Barry N. Kreiswirth.(2016).Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,60,(4)
MLA:
Hong Du,et al."Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 60..4(2016):2519-23