机构：[1]Department of Pathology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China[2]Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[3]Department of Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China[4]Department of Pathology, The Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China[5]Institute of Radiology and Oncology, Soochow University, Suzhou 215006, China
Inflammatory cells and mediators form a major part of the tumor microenvironment and play important roles in the regulation of cancer initiation, tumor cell proliferation, and metastasis. MicroRNAs (miRNAs) play important roles in several physiological and pathological processes, including the regulation of the inflammatory microenvironment in cancer. Transforming growth factor-beta (TGF-beta) is an inflammation-related cytokine that functions in both tumor suppression and promotion; however, its underlying molecular mechanisms remain unclear. Recent evidence indicates an association between miRNAs and TGF-beta signaling, providing new insight into the nature of the inflammatory microenvironment in cancer. The present review is an overview of the interaction between miRNAs and inflammatory cytokines, with emphasis on the cross talk between TGF-beta signaling and miRNAs and their influence on cancer cell behavior. The emerging roles of miRNAs in cancer-related inflammation and the potential to target miRNA signaling pathways for cancer therapy are also discussed.
基金：
The authors would like to acknowledge funding
from Chinese Nature Science Foundation (81272738, 81372867,
81472297) and project founded by the Priority Academic Program Development
of Jiangsu Higher Education Institutions.
第一作者机构：[1]Department of Pathology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pathology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, China[5]Institute of Radiology and Oncology, Soochow University, Suzhou 215006, China
推荐引用方式(GB/T 7714)：
Lingling Guo,Yongsheng Zhang,Lifeng Zhang,et al.MicroRNAs, TGF-beta signaling, and the inflammatory microenvironment in cancer[J].TUMOR BIOLOGY.2016,37(1):115-25.doi:10.1007/s13277-015-4374-2.
APA：
Lingling Guo,Yongsheng Zhang,Lifeng Zhang,Fengbo Huang,Jinfan Li&Shouli Wang.(2016).MicroRNAs, TGF-beta signaling, and the inflammatory microenvironment in cancer.TUMOR BIOLOGY,37,(1)
MLA：
Lingling Guo,et al."MicroRNAs, TGF-beta signaling, and the inflammatory microenvironment in cancer".TUMOR BIOLOGY 37..1(2016):115-25
