Objective: Patients with end-stage renal disease are susceptible to cardiac valve calcification (CVC) due to mineral metabolism disorders and other factors. The purpose of this study was to investigate the risk factors for new-onset CVC in patients on maintenance peritoneal dialysis (PD). Methods: This study included patients who underwent PD catheter insertion from January 2006 to June 2013 in our Peritoneal Dialysis Center. Clinical data were collected on CVC status during echocardiography evaluations (twice) at an interval of >6 months. The data collected included intact parathyroid hormone, C-reactive protein (CRP), serum phosphorus (P), serum calcium (Ca), albumin (Alb), prealbumin and the use of five types of antihypertensive drugs, statins, active vitamin D3 and Ca tablets. Results: In total, 194 patients 105 (54.1%) men, average age 60.5 +/- 13.0 years were included. CVC was present in 50 (25.8%) patients during PD catheter placement. After an average PD duration of 20.9 +/- 10.4 months, CVC was detected in 97 patients (50.0%). New-onset CVC was found in 62 patients (32.0%). Multivariate logistic regression analysis revealed that only serum P levels (p = 0.01, OR = 2.569), Alb levels (p = 0.04, OR = 0.935), dialysis duration (p = 0.03, OR = 1.039) and CRP levels (p = 0.02, OR = 1.031) were associated with CVC. Conclusion: Serum P, Alb and CRP levels as well as dialysis duration are independent risk factors for CVC. (C) 2016 S. Karger AG, Basel
基金：
Second Affiliated Hospital of Soochow University Preponderant Clinic Discipline Group Project; National Nature Science Foundation of China [81400762]; Key Talent's Subsidy Project in Science and Education, Suzhou, Jiangsu Province, China [KJXW2012011]; Science and Technology Project of Suzhou, Jiangsu Province, China [SYS201469]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区泌尿学与肾脏学
最新[2025]版：
大类|3 区医学
小类|4 区心脏和心血管系统4 区泌尿学与肾脏学
JCR分区：
出版当年[2014]版：
Q2UROLOGY & NEPHROLOGYQ3CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.
共同第一作者：
通讯作者：
通讯机构：[*]Department of Nephrology, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Jinchang District Suzhou, Jiangsu Province (China)
推荐引用方式(GB/T 7714)：
Tian Yunhuan,Feng Sheng,Zhan Zhoubing,et al.Risk Factors for New-Onset Cardiac Valve Calcification in Patients on Maintenance Peritoneal Dialysis[J].CARDIORENAL MEDICINE.2016,6(2):150-8.doi:10.1159/000443620.
APA：
Tian, Yunhuan,Feng, Sheng,Zhan, Zhoubing,Lu, Ying,Wang, Yancai...&Shen, Huaying.(2016).Risk Factors for New-Onset Cardiac Valve Calcification in Patients on Maintenance Peritoneal Dialysis.CARDIORENAL MEDICINE,6,(2)
MLA：
Tian, Yunhuan,et al."Risk Factors for New-Onset Cardiac Valve Calcification in Patients on Maintenance Peritoneal Dialysis".CARDIORENAL MEDICINE 6..2(2016):150-8
