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Metformin regulates differentiation of bone marrow-derived endothelial progenitor cells via multiple mechanisms

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资源类型：

收录情况： ◇ SCIE

作者：
Wen-Dong Li [1] * ; Xiao-Long Du [1] * ; Ai-Min Qian[1] ; Nan Hu[1] ; Ling-Shang Kong[1] ; Sen Wei[1] ; Cheng-Long Li[1] ; Xiao-Qiang Li[1,*1] ;
机构： [1]Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China
出处：
DOI： 10.1016/j.bbrc.2015.08.091
ISSN：

关键词： Metformin Endothelial progenitor cells Differentiation Autophagy Endothelial nitric oxide synthase Adenosine monophosphate activated protein kinase

摘要：
Objective: The aim of this study was to investigate the effect of metformin on endothelial progenitor cells (EPCs) differentiation and the possible mechanisms. Methods: EPCs were treated with metformin and differentiation, migration and tube formation of EPCs were evaluated. Moreover, we also assessed the AMPK-mTOR-p70SEK pathway, AMPK related autophagy pathway and eNOS-NO pathway to explore the mechanisms. Results: Metformin treatment could significantly increase differentiation of EPCs. On the mechanisms, increased level of AMPKand eNOS phosphorylation, LC3 expression and NO production, and decreased mTOR, p70 S6K as well as TGF-beta expression were found in EPCs. The AMPK inhibitor compound C, Atg5 knocking-down and eNOS inhibitor L-NAME could reverse the effect exerted by metformin. Conclusions: Our results here showed that metformin could regulate the differentiation of EPCs. Autophagy related pathway and AMPK-eNOS-NO pathway were involved in the mechanisms. (C) 2015 Elsevier Inc. All rights reserved.

基金：
This work was supported by grants from the National Natural Science Foundation of China (No.81400345, No.30972941), Jiangsu Provincial Health Department's Medical Science Program (No.H201211). Graduate Research and Innovation Program in Colleges and Universities of Jiangsu Province (No.1202).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2013]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构： [*1]Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, 1055, Sanxiang Rd, Suzhou 215000, Jiangsu, China.
推荐引用方式(GB/T 7714)：
Wen-Dong Li,Xiao-Long Du,Ai-Min Qian,et al.Metformin regulates differentiation of bone marrow-derived endothelial progenitor cells via multiple mechanisms[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2015,465(4):803-9.doi:10.1016/j.bbrc.2015.08.091.
APA：
Wen-Dong Li,Xiao-Long Du,Ai-Min Qian,Nan Hu,Ling-Shang Kong...&Xiao-Qiang Li.(2015).Metformin regulates differentiation of bone marrow-derived endothelial progenitor cells via multiple mechanisms.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,465,(4)
MLA：
Wen-Dong Li,et al."Metformin regulates differentiation of bone marrow-derived endothelial progenitor cells via multiple mechanisms".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 465..4(2015):803-9

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