机构：[a]Department of Neurology, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province 215021, China[b]College of Pharmacy and Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada[c]Department of Neurology, Shouguang People's Hospital, Shouguang, Shandong, China[d]Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China
Interleuldn-22 (IL-22) is a member of the IL-10 cytokine family that has recently gained attention in regard to its recognized pathogenic role in neurological and autoimmune disorders. The pathological involvement of IL-22 has been linked to Th17 cells that are involved in its production. Its biological activity results from its ability to bind to a heterodimeric receptor consisting of IL-22 receptor 1 (IL-22R1) and IL-10R2. Emerging evidence has identified IL-22 involvement in neurological diseases and autoimmune disorders such as Guillain-Barre Syndrome (GBS), multiple sclerosis (MS), Alzheimer's disease (AD), encephalitis, inflammatory myopathies, myasthenia gravis (MG), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), psoriasis and Crohn's disease (CD). However, the biological activity of IL-22 is variable resulting in protective or pathogenic effects in different disease states. As such, the development of therapeutic targeting strategies to modify the biological activity of IL-22 is being explored as a promising interventional approach to treat neurological and autoimmune diseases. (C) 2015 Elsevier B.V. All rights reserved.
基金：
Thisworkwas supported by theNational Nature Science Foundation
of China (81571579, 81072465), Natural Science Fund of the Educational
Committee of Jiangsu Province (10KJD320003), Special foundation of
president of the XuzhouMedical College (2010KJZ01), KeyMedical Talents
Fund of Jiangsu Province (H201130), and Jiangsu Province ordinary
university postgraduate research innovation fund (CXLX11_0734).
第一作者机构：[a]Department of Neurology, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu Province 215021, China
共同第一作者：
通讯作者：
通讯机构：[d]Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China
推荐引用方式(GB/T 7714)：
Ning Xin,Michael Peter Namaka,Changxin Dou,et al.Exploring the role of interleukin-22 in neurological and autoimmune disorders[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2015,28(2):1076-83.doi:10.1016/j.intimp.2015.08.016.
APA：
Ning Xin,Michael Peter Namaka,Changxin Dou&Yong Zhang.(2015).Exploring the role of interleukin-22 in neurological and autoimmune disorders.INTERNATIONAL IMMUNOPHARMACOLOGY,28,(2)
MLA：
Ning Xin,et al."Exploring the role of interleukin-22 in neurological and autoimmune disorders".INTERNATIONAL IMMUNOPHARMACOLOGY 28..2(2015):1076-83
医学