机构：[1]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China,[2]Department of Pathology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi 214006, China,[3]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China,[4]Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China,[5]Medical Lab, Northern Jiangsu People’s Hospital, Yangzhou 225001, China,[6]Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China
NBN plays a crucial role in carcinogenesis as a core component for both homologous recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand breaks (DSBs) repair pathways. Genetic variants in the NBN gene have been associated with multiple cancers risk, suggesting pleiotropic effect on cancer. We hypothesized that genetic variants in the NBN gene may modify the risk of gastric cancer. To test this hypothesis, we evaluated the association between four potentially functional single nucleotide polymorphisms in NBN and gastric cancer risk in a case-control study of 1,140 gastric cancer cases and 1,547 controls in a Chinese population. We found that the A allele of rs10464867 (G>A) was significantly associated with a decreased risk of gastric cancer (odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.71-0.94; P = 4.71x10(-3)). Furthermore, the association between A allele of rs10464867 and decreased risk of gastric cancer was more significantly in elder individuals (per-allele OR = 0.72[0.59-0.88], P = 1.07x10(-3)), and male individuals (per-allele OR = 0.73[0.62-0.87], P = 3.68x10(-4)). We further conducted a haplotype analysis and identified that the NBN A(rs10464867)G(rs14448)G(rs1063053) haplotype conferred stronger protective effect on gastric cancer (OR = 0.76[0.65-0.89], P = 6.39x10(-4)). In summary, these findings indicate that genetic variants at NBN gene may contribute to gastric cancer susceptibility and may further advance our understanding of NBN gene in cancer development.
基金：
81230067,
National Natural Science Foundation of China, HS;
81422042 and 81373090,
National Natural Science Foundation of China, GJ;
BK20130042, Science and
Technology Agency of Jiangsu Province, China, GJ;
BL2012008, Science and
Technology committee of Nanjing, China, HS; Government of Jiangsu
Province, China, HS; Science Foundation for Distinguished Young Scholars in Jiangsu
(BK20130042); Jiangsu Province Clinical Science
and Technology Projects (Clinical Research Center,
BL2012008); and Priority Academic Program for the
Development of Jiangsu Higher Education Institutions
(Public Health and Preventive Medicine).
第一作者机构：[1]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China,[2]Department of Pathology, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi 214006, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China,[3]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China,[4]Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China,
推荐引用方式(GB/T 7714)：
Ping Sun,Jiangbo Du,Xun Zhu,et al.Genetic Variation in the 3 '-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population[J].PLOS ONE.2015,10(9):e0139059.doi:10.1371/journal.pone.0139059.
APA：
Ping Sun,Jiangbo Du,Xun Zhu,Chuanli Ren,Lan Xie...&Guangfu Jin.(2015).Genetic Variation in the 3 '-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population.PLOS ONE,10,(9)
MLA：
Ping Sun,et al."Genetic Variation in the 3 '-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population".PLOS ONE 10..9(2015):e0139059
