机构：[1]Department of Genetics, Medical College of Soochow University, Suzhou, China[2]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]The Institute for Chemical Carcinogenesis, The State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Long intergenic noncoding RNAs (lincRNAs) have critical regulatory roles in cancer biology; however, the contributions of lincRNAs to esophageal squamous cell carcinoma (ESCC) have been infrequently explored. The aim of this study was to explore the contribution of lincRNAs, located at ESCC susceptibility loci identified by genome-wide association studies, to the risk and prognosis of ESCC. The associations between lincRNAs and the risk and prognosis of ESCC were analyzed in 358 diagnosed patients from eastern China, and the findings were validated in 326 additional patients from southern China. Functional relevance of lincRNAs was further examined by biochemical assays. We found that lincRNA-uc002yug.2 was commonly overexpressed in ESCC compared with paired peritumoral tissue in eastern and southern Chinese populations. The expression levels of lincRNA-uc002yug.2 in ESCC might be a prognostic factor for survival. Moreover, lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1 alpha, the short isoform and inhibitor of RUNX1, and reduce CEBP alpha (CCAAT/enhancer-binding protein-alpha) gene expression, thereby promoting ESCC progression. These results indicated that lincRNA-uc002yug.2 might involve in AS of RUNX1/AML1 and serve as a predictor for esophageal cancer and prognosis.
基金：
This study was supported by the National Scientific Foundation of China grants
81001278, 81171895, 81472630 and 81072366; a project funded by the Priority
Academic Program Development of Jiangsu Higher Education Institutions, Jiangsu
Provincial Natural Science Foundation (No. BK2011297); Jiangsu Province Science and
Technology Support Program (No. BE2012648) and the Scientific Research
Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
(No. 20101561).
第一作者机构：[1]Department of Genetics, Medical College of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Genetics, Medical College of Soochow University, Renai Road No.199, Buliding 401, Room 1418, Suzhou 215123, China.
推荐引用方式(GB/T 7714)：
H Wu,J Zheng,J Deng,et al.LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis[J].ONCOGENE.2015,34(36):4723-34.doi:10.1038/onc.2014.400.
APA：
H Wu,J Zheng,J Deng,L Zhang,N Li...&Y Zhou.(2015).LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis.ONCOGENE,34,(36)
MLA：
H Wu,et al."LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis".ONCOGENE 34..36(2015):4723-34
医学