Background: Catheter-directed thrombolysis (CDT) has been a mainstay in treating deep venous thrombosis (DVT). However, the optimal dosage of a thrombolytic agent is still controversial. The goal of this study was to evaluate the safety and efficacy of low dosage urokinase with CDT for DVT. Methods: A retrospective analysis was performed using data from a total of 427 patients with DVT treated with CDT in our single center between July 2009 and December 2012. Early efficacy of thrombolysis was assessed with a thrombus score based on daily venography. The therapeutic safety was evaluated by adverse events. A venography or duplex ultrasound was performed to assess the outcome at 6 months, 1 year and 2 years postoperatively. Results: The mean total dose of 3.34 (standard deviation [SD] 1.38) million units of urokinase was administered during a mean of 5.18 (SD 2.28) days. Prior to discharge, Grade III (complete lysis) was achieved in 154 (36%) patients; Grade II (50-99% lysis) in 222 (52%); and Grade I (50% lysis) in 51 (12%). The major complications included one intracranial hemorrhage, one hematochezia, five gross hematuria, and one pulmonary embolism. Moreover, no death occurred in the study. Conclusions: Treatment of low-dose catheter-directed thrombosis is an efficacious and safe therapeutic approach in patients with DVT offering good long-term outcomes and minimal complications.
基金：
This work was supported by a grant from the
Key Research Project of Health Department of Jiangsu Province
(No. H201211)
第一作者机构：[1]Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou 215000, Jiangsu, China
通讯作者：
通讯机构：[1]Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou 215000, Jiangsu, China
推荐引用方式(GB/T 7714)：
Du Xiao-Long,Kong Ling-Shang,Meng Qing-You,et al.Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis[J].CHINESE MEDICAL JOURNAL.2015,128(13):1787-92.doi:10.4103/0366-6999.159355.
APA：
Du, Xiao-Long,Kong, Ling-Shang,Meng, Qing-You,Qian, Aimin,Li, Wen-Dong...&Li, Cheng-Long.(2015).Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis.CHINESE MEDICAL JOURNAL,128,(13)
MLA：
Du, Xiao-Long,et al."Safety and Efficacy of Low Dosage of Urokinase for Catheter-directed Thrombolysis of Deep Venous Thrombosis".CHINESE MEDICAL JOURNAL 128..13(2015):1787-92
