机构：[a]Institute of Medical Biotechnology, Suzhou Health College, Suzhou, Jiangsu 215009, PR China[b]Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215007, PR China[c]Wuxi Red Cross Blood Center, Wuxi, PR China[d]Department of Special Requirements Ward, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, PR China[e]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, PR China
CD276 (B7-H3) is a costimulatory molecule that plays a potent role in T cell responses, however, the role of B7-H3 in autoimmune diseases has not been elucidated. We analyzed B7-H3 expression in rheumatoid arthritis (RA) for the first time and found B7-H3 was significantly up-regulated on monocytes in RA patients, while the levels of soluble B7-H3 in serum were lower than in controls (P < 0.0001). These differences correlated with clinical and laboratory disease parameters and informatory factor TNF-alpha. Through in vitro experiments, we demonstrated that B7-H3 promoted TNF-alpha secretion. In addition, a new polymorphism variant, B7-H3-T-A-C-T, was identified and shown to be associated with the incidence of RA and the decreased release of sB7-H3. These results suggest that B7-H3 may be a promising biomarker associated with the pathogenesis of RA. Notably, the new B7-H3-T-A-C-T polymorphism variant is associated with RA risk and might be associated with the release of soluble B7-H3. (C) 2015 Elsevier Inc. All rights reserved.
基金：
This work was supported by grants from the National Natural
Science Foundation of China (no. 31100626, no. 31170834, no.
81301494), the National Natural Science Foundation of Jiangsu
province (no. BK2011320), Qing Lan project (Sunjing), the
National Basic Research Development Program of China (973
Program, no. 2013CB530501) and the Science and Technology
project of Suzhou (no. SYS201331).
第一作者机构：[a]Institute of Medical Biotechnology, Suzhou Health College, Suzhou, Jiangsu 215009, PR China
共同第一作者：
通讯作者：
通讯机构：[a]Institute of Medical Biotechnology, Suzhou Health College, Suzhou, Jiangsu 215009, PR China[b]Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215007, PR China
推荐引用方式(GB/T 7714)：
Jing Sun,Cuiping Liu,Li Gao,et al.Correlation between B7-H3 expression and rheumatoid arthritis: A new polymorphism haplotype is associated with increased disease risk[J].CLINICAL IMMUNOLOGY.2015,159(1):23-32.doi:10.1016/j.clim.2015.04.012.
APA：
Jing Sun,Cuiping Liu,Li Gao,Yundi Guo,Yaqin Zhang...&Xueguang Zhang.(2015).Correlation between B7-H3 expression and rheumatoid arthritis: A new polymorphism haplotype is associated with increased disease risk.CLINICAL IMMUNOLOGY,159,(1)
MLA：
Jing Sun,et al."Correlation between B7-H3 expression and rheumatoid arthritis: A new polymorphism haplotype is associated with increased disease risk".CLINICAL IMMUNOLOGY 159..1(2015):23-32
