机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, The Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou City 215004, Jiangsu Province, China[2]The Institute of Neuroscience, Soochow University, Suzhou City, China
Cystatin C (CysC) has been used as a renal function indicator and a strong predictor of cardiovascular events. In this study, we determined the prognostic value of serum CysC in patients with acute ischemic stroke (AIS) and examined its protective role on ischemic brain injury. First-ever stroke patients (601 cases) and control subjects (325 cases) were recruited. Serum CysC level in patients with AIS were significantly higher than that in controls. Multivariate logistic regression analyses showed that elevated CysC is an independent risk factor of AIS; the odds ratio (95 % confidence interval) was 9.80 (3.12-30.83). The integrated population was divided into quintiles according to serum CysC. Compared with the first quintile, the odds ratios of risk for AIS in fourth quintile and fifth quintile were 1.92 (1.08-3.40) and 2.88 (1.49-5.54), respectively. Serum CysC was not associated with neurological deficits and the location of ischemic area; however, serum CysC in patients decreased after one-week therapy. This was consistent with CysC expression after ischemia/reperfusion injury in a mouse focal ischemia/reperfusion injury model. Exogenous CysC exerted neuroprotective effects by reducing infarct volume in this animal stroke model. Therefore, serum CysC is highly associated with AIS and is an independent prediction marker for AIS. Since our findings demonstrated the protection of exogenous CysC on ischemic brain injury, CysC is a novel and promising therapeutic target for AIS.
基金：
This study was supported by the grants from the
National Natural Science Foundation of China (81071095,
81120108011, and 81361128010) and the Priority Academic Program
Development of Jiangsu Higher Education Institutions of China
第一作者机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, The Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou City 215004, Jiangsu Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, The Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou City 215004, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Bo Yang,Jiangtao Zhu,Zhigang Miao,et al.Cystatin C is an Independent Risk Factor and Therapeutic Target for Acute Ischemic Stroke[J].NEUROTOXICITY RESEARCH.2015,28(1):1-7.doi:10.1007/s12640-015-9522-3.
APA：
Bo Yang,Jiangtao Zhu,Zhigang Miao,Beiqun Zhou,Wei Ge...&Xingshun Xu.(2015).Cystatin C is an Independent Risk Factor and Therapeutic Target for Acute Ischemic Stroke.NEUROTOXICITY RESEARCH,28,(1)
MLA：
Bo Yang,et al."Cystatin C is an Independent Risk Factor and Therapeutic Target for Acute Ischemic Stroke".NEUROTOXICITY RESEARCH 28..1(2015):1-7
