机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, People’s Republic of China[2]Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, China[3]Department of Pathophysiology, Medical School of Nantong University, Nantong, 226001, Jiangsu Province, China
This study aimed to investigate molecule B7-H3 expression profiles of patients with ankylosing spondylitis (AS) and the clinical significance of B7-H3 in the pathogenesis of AS. Serum B7-H3 levels were measured by ELISA in patients with AS and healthy controls. The expression of B7-H3 protein and mRNA on CD14+ monocytes of peripheral blood mononuclear cells (PBMCs) and serum levels of T cell-associated cytokines were also analyzed. The serum B7-H3 levels in AS patients were significantly lower than in healthy controls. The expression of B7-H3 protein and mRNA on CD14+ monocytes of PBMCs and serum levels of TNF-alpha, IL-6, and IL-17A in AS patients were significantly higher than in controls. The reduced serum B7-H3 level was highly negatively correlated with AS Disease Activity Score (ASDAS), TNF-alpha, and IL-17A. Upregulated B7-H3 protein may play a role in the pathogenesis of AS by binding its receptor on T cells.
基金：
This research was supported by the grant from the
National Natural Science Foundation of China
(81301494).
第一作者机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Medical Equipment, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, China
推荐引用方式(GB/T 7714)：
Ruhong Yan,Yae Hu,Peijuan Yu,et al.Reduced Serum B7-H3 Levels in Patients with Ankylosing Spondylitis[J].INFLAMMATION.2015,38(3):1322-8.doi:10.1007/s10753-014-0103-z.
APA：
Ruhong Yan,Yae Hu,Peijuan Yu,Huiyan Wen,Ping Feng&Shun Yang.(2015).Reduced Serum B7-H3 Levels in Patients with Ankylosing Spondylitis.INFLAMMATION,38,(3)
MLA：
Ruhong Yan,et al."Reduced Serum B7-H3 Levels in Patients with Ankylosing Spondylitis".INFLAMMATION 38..3(2015):1322-8
