机构：[1]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Radiation Oncology, The First People’s Hospital of Xuzhou, Xuzhou, China[3]Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China[4]Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA[5]Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan[6]Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China[7]Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Objectives: To evaluate levels of CD44 standard variant (CD44s), CD44 variant exon 3 (CD44v3) and CD44 variant exon 6 (CD44v6) protein in breast cancer tissue, and investigate their relationships with clinicopathological characteristics of the disease. Methods: Immunohistochemistry for CD44s, CD44v3 and CD44v6 was retrospectively performed on formalin-fixed paraffin wax-embedded breast cancer tissue samples. Results: Tumour tissue samples from 60 patients with breast cancer were included. There was a significant relationship between CD44s positivity and tumour diameter and lymph node involvement. CD44v6 positivity was significantly associated with tumour-node-metastasis (TNM) stage and lymph node involvement. There were significant negative correlations between CD44s immunopositivity, tumour diameter and TNM stage, and significant positive correlations between CD44v6 immunopositivity, tumour diameter and TNM stage. Conclusions: CD44s and CD44v6 appear to play opposing roles in the development of breast cancer, but their precise functions and mechanisms of action remain unclear.
基金：
This work was supported by a grant
from the Jiangsu Health International
Exchange Supporting Program
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2013]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Radiation Oncology, The First People’s Hospital of Xuzhou, Xuzhou, China
共同第一作者：
通讯作者：
通讯机构：[*]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu Province, China.
推荐引用方式(GB/T 7714)：
Xiao-Jin Wu,Xiao-Dong Li,Hanze Zhang,et al.Clinical significance of CD44s, CD44v3 and CD44v6 in breast cancer[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2015,43(2):173-9.doi:10.1177/0300060514559793.
APA：
Xiao-Jin Wu,Xiao-Dong Li,Hanze Zhang,Xiaofei Zhang,Zhong-Hua Ning...&Ye Tian.(2015).Clinical significance of CD44s, CD44v3 and CD44v6 in breast cancer.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,43,(2)
MLA：
Xiao-Jin Wu,et al."Clinical significance of CD44s, CD44v3 and CD44v6 in breast cancer".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 43..2(2015):173-9
