机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, #1055 Sanxiang Road, Suzhou 215004, Jiangsu, China[2]Department of Neurosurgery, Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, China[3]Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China[4]Modern Medical Research Center, Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, China
microRNAs (miRNAs) are a class of small non-coding RNAs, approximately 21-25 nucleotides in length. Recently, some researchers have demonstrated that plasma miRNAs are sensitive and specific biomarkers of various cancers. Using quantitative real-time PCR, the expression levels of miR-454-3p were compared between pre-operative plasmas from 70 glioma patients and 70 healthy controls, and between these pre-operative and post-operative plasmas. Kaplan-Meier analysis was used to evaluate the association of miR-454-3p with prognosis of glioma patients. The expression levels of miR-454-3p in plasma in glioma patients were significantly higher than that from healthy controls. The expression levels of miR-454-3p were higher in high grade gliomas than in low grade gliomas. The AUC of the expression of miR-454-3p in plasma for glioma diagnosis was 0.9063. The expression levels of miR-454-3p in the post-operative plasmas were significantly downregulated when compared to the pre-operative plasmas. Moreover, the prognosis of glioma with high miR-454-3p expression was significantly worse compared with that of glioma with low miR-454-3p expression. Our results suggested that plasma miR-454-3p could be a novel potential diagnostic biomarker for glioma.
基金：
This work was supported by National Natural
Science Foundation of China Projects 31071046 and 81302197,
Changzhou Science Development Project (CS20102010) and
Changzhou Health Bureau Key Project (ZD201007).
第一作者机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, #1055 Sanxiang Road, Suzhou 215004, Jiangsu, China[2]Department of Neurosurgery, Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, #1055 Sanxiang Road, Suzhou 215004, Jiangsu, China
推荐引用方式(GB/T 7714)：
Naiyuan Shao,Lei Wang,Lian Xue,et al.Plasma miR-454-3p as a potential prognostic indicator in human glioma[J].NEUROLOGICAL SCIENCES.2015,36(2):309-13.doi:10.1007/s10072-014-1938-7.
APA：
Naiyuan Shao,Lei Wang,Lian Xue,Rong Wang&Qing Lan.(2015).Plasma miR-454-3p as a potential prognostic indicator in human glioma.NEUROLOGICAL SCIENCES,36,(2)
MLA：
Naiyuan Shao,et al."Plasma miR-454-3p as a potential prognostic indicator in human glioma".NEUROLOGICAL SCIENCES 36..2(2015):309-13
