机构：[a]Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA[b]Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China[c]Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA[d]Department of Neurology, Oregon Health and Science University and Portland VA Medical Center, Portland, OR, USA[e]Department of Neurosciences, University of California San Diego, La Jolla, CA, USA[f]Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA[g]VA Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
Clinically diagnosed Alzheimer's disease (AD) is pathologically heterogeneous. In this multicenter cohort of 215 clinically diagnosed AD patients and 249 controls, E-selectin and vascular cell adhesion molecule 1 (VACM-1) were measured along with amyloid-beta peptide 1-42 (A beta(42)) and tau. We discovered that E-selectin, a biomarker of endothelial function/vascular injury, was inversely correlated with cerebrospinal fluid (CSF) tau/A beta(42) ratio and significantly elevated in clinical AD patients without the typical AD CSF biomarker signature (i.e., low tau/A beta(42) ratio) compared to those with the signature. These findings suggest that E-selectin may be an objective biomarker related to vascular mechanisms contributing to dementia.
基金：
The work was supported
by several grants (AG05136, AG023185, AG08017
and NS082137), an anonymous foundation, the Shaw
endowment, and the Department of Veterans Affairs.
第一作者机构：[a]Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA[f]Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Pathology, University of Washington, 325 9th Ave, Seattle, WA 98104, USA
推荐引用方式(GB/T 7714)：
Ge Li,Kangping Xiong,Ane Korff,et al.Increased CSF E-Selectin in Clinical Alzheimer's Disease without Altered CSF A beta(42) and Tau[J].JOURNAL OF ALZHEIMERS DISEASE.2015,47(4):883-7.doi:10.3233/JAD-150420.
APA：
Ge Li,Kangping Xiong,Ane Korff,Catherine Pan,Joseph F. Quinn...&Jing Zhang.(2015).Increased CSF E-Selectin in Clinical Alzheimer's Disease without Altered CSF A beta(42) and Tau.JOURNAL OF ALZHEIMERS DISEASE,47,(4)
MLA：
Ge Li,et al."Increased CSF E-Selectin in Clinical Alzheimer's Disease without Altered CSF A beta(42) and Tau".JOURNAL OF ALZHEIMERS DISEASE 47..4(2015):883-7
