机构：[1]Department of Neurology and Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, the Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China,[2]The Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China,[3]The Institute of Neuroscience, Soochow University, Suzhou City, Jiangsu Province, China,[4]Department of Neurology, Suzhou Kowloon Hospital, Suzhou City, Jiangsu Province, China
Major depression is becoming one of the most prevalent forms of psychiatric disorders. However, the mechanisms of major depression are still not well-understood. Most antidepressants are only effective in some patients and produce some serious side effects. Animal models of depression are therefore essential to unravel the mechanisms of depression and to develop novel therapeutic strategies. Our previous studies showed that Abelson helper integration site-1 (Ahi1) deficiency causes depression-like behaviors in mice. In this study, we characterized the biochemical and behavioral changes in Ahi1 knockout (KO) mice. In Ahi1 KO mice, neurotransmitters including serotonin and dopamine were significantly decreased in different brain regions. However, glutamate and GABA levels were not affected by Ahi1 deficiency. The antidepressant imipramine attenuated depressive behaviors and partially restored brain serotonin level in Ahi1 KO mice. Our findings suggest that Ahi1 KO mice can be used for studying the mechanisms of depression and screening therapeutic targets.
基金：
This study was supported by grants 81071095, 81120108011, and 813111078 (to XX) from the National Natural Science Foundation of China, Suzhou
science and technology development program (SYS201232), the Priority Academic Program Development of Jiangsu Higher Education Institutions of China,
Jiangsu Province’s Key Provincial Talents Program (to XX), and the National Basic Research Program of China (973 Program, 2013CB945401, to MS).
第一作者机构：[1]Department of Neurology and Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, the Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, the Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China,[3]The Institute of Neuroscience, Soochow University, Suzhou City, Jiangsu Province, China,
推荐引用方式(GB/T 7714)：
Liyan Ren,Xuanchen Qian,Lijing Zhai,et al.Loss of Ahi1 Impairs Neurotransmitter Release and Causes Depressive Behaviors in Mice[J].PLOS ONE.2014,9(4):e93640.doi:10.1371/journal.pone.0093640.
APA：
Liyan Ren,Xuanchen Qian,Lijing Zhai,Miao Sun,Zhigang Miao...&Xingshun Xu.(2014).Loss of Ahi1 Impairs Neurotransmitter Release and Causes Depressive Behaviors in Mice.PLOS ONE,9,(4)
MLA：
Liyan Ren,et al."Loss of Ahi1 Impairs Neurotransmitter Release and Causes Depressive Behaviors in Mice".PLOS ONE 9..4(2014):e93640
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