机构：[1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004[2]School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, P.R. China
Digestive tumors have the highest incidence among all tumor types worldwide. miR-146a has been shown to play an important role in the development, apoptosis, invasion and metastasis of digestive tumors. Additionally, a miR-146a gene polymorphism has been associated with the risk of a variety of cancer types in the digestive system. Therefore, in order to investigate the correlation, a meta-analysis of reported data was conducted, for which we obtained 21 research studies concerning the association between the miR-146a gene polymorphism and digestive tumors. Odds ratio (OR) values and 95% confidence intervals (95% CI) were used to assess this association. We found that the miR-146a polymorphism rs2910164 might significantly increase the susceptibility of digestive tumors, in particular for esophageal cancer and colorectal cancers. Furthermore, the miR-146a polymorphism might significantly increase the risk of digestive tumors in Asians. However, no obvious correlation between the polymorphism and the risk for digestive tumors was found in Caucasians.
基金：
The present study was partially supported by the National Natural Science Foundation of China (grant nos. 81172348, 81102078 and 81172597), Health Research Projects in Jiangsu Province (H201313) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
第一作者机构：[1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004
共同第一作者：
通讯作者：
通讯机构：[*1]Department of General Surgery, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxian Road, Suzhou 215004, P.R. China[*2]School of Radiation Medicine and Protection, Medical College of Soochow University, No. 199, Renai Road, Suzhou 215123, P.R. China
推荐引用方式(GB/T 7714)：
XIAOHUI XU,XIAODONG YANG,GAN RU,et al.miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies[J].ONCOLOGY REPORTS.2014,31(1):472-9.doi:10.3892/or.2013.2854.
APA：
XIAOHUI XU,XIAODONG YANG,GAN RU,YONG WU,SHUYU ZHANG...&JIANPING CAO.(2014).miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies.ONCOLOGY REPORTS,31,(1)
MLA：
XIAOHUI XU,et al."miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies".ONCOLOGY REPORTS 31..1(2014):472-9
