机构：[1]Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou, China[2]State Key Laboratory of Genetic Engineering, Fudan-VARI Genetic Epidemiology Center and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China[3]Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China
The clinical significance of SLC7A7 expression remains unclear. In this study, we aimed to explore whether SLC7A7 expression in tumor tissues could be used to assess subsequent prognosis in patients with glioblastoma (GBM). A total of 119 patients with pathologically confirmed GBM and 16 normal controls were recruited for this study. The expression of SLC7A7 in GBM and normal tissues was evaluated by immunohistochemistry in tissue microarrays and quantitative real-time PCR. Kaplan-Meier method and Cox's proportional hazards model were used in survival analysis. Compared with normal tissues, GBM specimens had significantly increased expression of SLC7A7 at both mRNA and protein levels (both P < 0.05). Moreover, multivariate analysis confirmed that overexpression of SLC7A7 was a significant and independent indicator for predicting poor prognosis. Our results suggest, for the first time, that overexpression of SLC7A7 is correlated with worse outcomes in patients with GBM. SLC7A7 plays a critical role in GBM carcinogenesis and may be a potential prognosis predictor of GBM.
基金：
This work was supported
by the Shanghai Science and Technology Research Program (Grants
09JC1402200 and 10410709100) and the Natural Science Foundation
of China (Grants 30800622 and 81001114).
第一作者机构：[1]Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China
推荐引用方式(GB/T 7714)：
Songhua Fan,Delong Meng,Tao Xu,et al.Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma[J].MEDICAL ONCOLOGY.2013,30(1):384.doi:10.1007/s12032-012-0384-8.
APA：
Songhua Fan,Delong Meng,Tao Xu,Yuanyuan Chen,Jingkun Wang...&Qing Lan.(2013).Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma.MEDICAL ONCOLOGY,30,(1)
MLA：
Songhua Fan,et al."Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma".MEDICAL ONCOLOGY 30..1(2013):384
