机构：[1]The Second Affiliated Hospital of Soochow University, Department of Orthopaedics, China, Jiangsu Province, 1055 Sanxiang Road, Suzhou, Jiangsu, China,[2]School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China,[3]Department of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu, China,[4]Orthopaedic Research Institution, Soochow University, Suzhou, Jiangsu, China,[5]Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Iron overload is widely regarded as a risk factor for osteoporosis. It has been demonstrated that iron can inhibit osteoblast differentiation. However, the effects of iron on osteoclast differentiation and bone resorption remain controversial. In this study, we found that ferric ion promoted Receptor Activator of Nuclear Factor ? B Ligand (RANKL)-induced osteoclast (OC) formation in both RAW264.7 cells and bone marrow-derived macrophages (BMMs), and this effect was accompanied by elevated levels of reactive oxygen species (ROS) and oxidative stress. Moreover, this effect was attenuated by the administration of antioxidant N-acetyl-L-cysteine (NAC). Therefore, we conclude that ferric ion can promote osteoclast differentiation and bone resorption through the production of ROS. (c) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:18431852, 2012
基金：
This study was supported by education ministry grants
(20103201110020).
第一作者机构：[1]The Second Affiliated Hospital of Soochow University, Department of Orthopaedics, China, Jiangsu Province, 1055 Sanxiang Road, Suzhou, Jiangsu, China,
通讯作者：
通讯机构：[1]The Second Affiliated Hospital of Soochow University, Department of Orthopaedics, China, Jiangsu Province, 1055 Sanxiang Road, Suzhou, Jiangsu, China,
推荐引用方式(GB/T 7714)：
Peng Jia ,You Jia Xu ,Zeng Li Zhang ,et al.Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species[J].JOURNAL OF ORTHOPAEDIC RESEARCH.2012,30(11):1843-52.doi:10.1002/jor.22133.
APA：
Peng Jia,,You Jia Xu,,Zeng Li Zhang,,Kai Li,,Bingyan Li,...&Huilin Yang.(2012).Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species.JOURNAL OF ORTHOPAEDIC RESEARCH,30,(11)
MLA：
Peng Jia,,et al."Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species".JOURNAL OF ORTHOPAEDIC RESEARCH 30..11(2012):1843-52
