机构:[1]Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China,[2]Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
Trimetazidine, a piperazine derivative used as an anti-anginal agent, improves myocardial glucose utilization through inhibition of fatty acid metabolism. The present study was designed to investigate whether trimetazidine has the protective effects against smoking-induced left ventricular remodeling in rats. In this study, Wistar rats were randomly divided into 3 groups: smoking group (exposed to cigarette smoke), trimetazidine group (exposed to cigarette smoke and treated with trimetazidine), and control group. The echocardiographic and morphometric data indicated that trimetazidine has protective effects against smoking-induced left ventricular remodeling. Oxidative stress was evaluated by detecting malondialdehyde, superoxide dismutase, and glutathione peroxidase in the supernatant of left ventricular tissue. Cardiomyocyte apoptotic rate was determined by flow cytometry with Annexin V/PI staining. Gene expression and serum levels of inflammatory markers, including interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, were deteced by quantitative real-time PCR and enzyme-linked immunosorbent assay. Our results suggested that trimetazidine could significantly reduce smoking-induced oxidative stress, apoptosis, and inflammation. In conclusion, our study demonstrates that trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation.
基金:
This study was supported by the academic research grants of the Second Affiliated Hospital of Soochow University
第一作者机构:[1]Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China,
通讯作者:
通讯机构:[1]Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China,
推荐引用方式(GB/T 7714):
Xiang Zhou,Chao Li,Weiting Xu,et al.Trimetazidine Protects against Smoking-Induced Left Ventricular Remodeling via Attenuating Oxidative Stress, Apoptosis, and Inflammation[J].PLOS ONE.2012,7(7):e40424.doi:10.1371/journal.pone.0040424.
APA:
Xiang Zhou,Chao Li,Weiting Xu&Jianchang Chen.(2012).Trimetazidine Protects against Smoking-Induced Left Ventricular Remodeling via Attenuating Oxidative Stress, Apoptosis, and Inflammation.PLOS ONE,7,(7)
MLA:
Xiang Zhou,et al."Trimetazidine Protects against Smoking-Induced Left Ventricular Remodeling via Attenuating Oxidative Stress, Apoptosis, and Inflammation".PLOS ONE 7..7(2012):e40424