机构：[1]Molecular Medicine Center, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Laboratory of Molecular Medicine, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China[3]Nanjing Maternity & Child Health Hospital Affiliated Hospital of Nanjing Medical University, Nanjing 210004, China[4]State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Since the first case reported in 1981, more than 60 million individuals have succumbed to HIV worldwide. Although great efforts have been put forth in developing therapeutic drugs and effective vaccines for the treatment and prevention of HIV infection, these efforts are not correlated to the reported case of cured HIV infection. The first case of cured HIV infection, from allogenic stem cell transplantation, may shed light on future prevention and therapy of HIV infection. The choice of gene target, however, must first be evaluated regarding stem cell based gene therapy for HIV infection. Out of the tens of genes that had shown anti-HIV infection potentials, CCR5 was described to be effective in stem cell based gene therapy in 2005. Here, we appreciate the clinical observations that directly led to the choice of CCR5, rather than other genes for stem cell gene therapy.
基金：
This study is partially supported
by National Natural Science Foundation of China (No.
30970877, 60927001), Chinese National 863 major grant
(2008AA02Z436), and the National Key Program for
Developing Basic Research of China (2010CB933903).
第一作者机构：[1]Molecular Medicine Center, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
通讯作者：
通讯机构：[2]Laboratory of Molecular Medicine, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China[3]Nanjing Maternity & Child Health Hospital Affiliated Hospital of Nanjing Medical University, Nanjing 210004, China
推荐引用方式(GB/T 7714)：
Jia Zhang,Alice Saint Sinoasia Li,Xiaojin Kou,et al.Why CCR5 is Chosen as the Target for Stem Cell Gene Therapy for HIV Infection?[J].JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY.2012,12(3):2045-8.doi:10.1166/jnn.2012.5179.
APA：
Jia Zhang,Alice Saint Sinoasia Li,Xiaojin Kou,Li Xiao,Ping Li...&Kai Li.(2012).Why CCR5 is Chosen as the Target for Stem Cell Gene Therapy for HIV Infection?.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,12,(3)
MLA：
Jia Zhang,et al."Why CCR5 is Chosen as the Target for Stem Cell Gene Therapy for HIV Infection?".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 12..3(2012):2045-8
