机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[2]Department of Neurology, Chengdu Fifth People’s Hospital, Chengdu, China,[3]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China,[4]Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Beijing, China,[5]Department of Psychology, University of Chinese Academy of Sciences (CAS), Beijing, China,[6]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China,放射科首都医科大学宣武医院[7]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,首都医科大学宣武医院核医学科[8]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China,[9]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[10]Beijing Institute of Geriatrics, Beijing, China,[11]National Clinical Research Center for Geriatric Disorders, Beijing, China
The abnormality occurs at molecular, cellular as well as network levels in patients with Alzheimer's disease (AD) prior to diagnosis. Most previous connectivity studies were conducted at 1 out of 3 (local, meso and global) scales in subjects covering only part of the entire AD spectrum (subjective cognitive decline, SCD; amnestic mild cognitive impairment, aMCI; and then fully manifest AD). Data interpretation within the framework of disease progression is therefore difficult. The current study included 3 age- and sex-matched cohorts: SCD (n = 32), aMCI (n = 37) and fully-established AD (n = 30). A group of healthy elderly subjects (n = 40) were included as a normal control (NC). Network connectivity was examined at the local (degree centrality), meso [subgraph centrality (SC)], and global (eigenvector and page-rank centralities) levels. As compared to NC, SCD subjects had isolated decrease of SC in primary (somatomotor and visual) networks. aMCI subjects had decreased centralities at all three scales in associative (frontoparietal control, dorsal attention, limbic and default) networks. AD subjects had increased centrality at the global scale in all seven networks. There was a positive association between Montreal Cognitive Assessment (MoCA) scores and DC in the frontoparietal control network in SCD, a negative relationship between Mini-Mental State Examination (MMSE) scores and EC in the somatomotor network in AD. These findings suggest that the primary network is impaired as early as in SCD. Impairment in the associative network also starts at the local level at this stage and may contribute to the cognitive decline. As associative network impairment extends from local to meso and global scales in aMCI, compensatory mechanisms in the primary network are activated.
基金：
National Key Research and Development Program of China [2016YFC1306300, 2016YFC0103000]; National Natural Science Foundation of China [61633018, 81801052, 81522021, 81430037, 81471731]; Beijing Nature Science Foundation [7161009]; Beijing Municipal Commission of Health and Family Planning [PXM2019_026283_000002]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Department of Neurology, Chengdu Fifth People’s Hospital, Chengdu, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[9]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[10]Beijing Institute of Geriatrics, Beijing, China,[11]National Clinical Research Center for Geriatric Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Ziqi Wang,Kaini Qiao,Guanqun Chen,et al.Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease[J].FRONTIERS IN NEUROINFORMATICS.2019,13:doi:10.3389/fninf.2019.00026.
APA：
Ziqi Wang,Kaini Qiao,Guanqun Chen,Danyang Sui,Hao-Ming Dong...&Ying Han.(2019).Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease.FRONTIERS IN NEUROINFORMATICS,13,
MLA：
Ziqi Wang,et al."Functional Connectivity Changes Across the Spectrum of Subjective Cognitive Decline, Amnestic Mild Cognitive Impairment and Alzheimer's Disease".FRONTIERS IN NEUROINFORMATICS 13.(2019)
