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Concordance for Parkinson's disease in twins: A 20-year update

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收录情况： ◇ SCIE

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机构： [1]Division of Occupational and Environmental Medicine, University of California-San Francisco, San Francisco Veterans Affairs Health Care System, University of California–San Francisco, San Francisco, CA [2]Institute for Neurodegenerative Disorders, New Haven, CT [3]G.H. Sergievsky Center, Columbia University, New York, NY [4]Department of Neurology, University of California–San Francisco, San Francisco, CA [5]Department of Neurobiology and Neurology, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China [6]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [7]Department of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada [8]Department of Pathology, Stanford University, Palo Alto, CA [9]VA Pacific Islands Health Care System, Pacific Health Research and Education Institute, Honolulu, HI [10]Department of Neurology, University of California-San Francisco, San Francisco Veterans Affairs Health Care System, University of California-San Francisco, San Francisco, CA

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During the 1990s, we estimated the genetic contribution to Parkinson's disease risk in a large, population-based twin registry. Because many unaffected twins were still alive, previous concordance estimates were based on incomplete information. Ninety-five percent of twins are now deceased. Here, we update concordance and heritability through 2015 using National Death Index data. In total, we identified 30 concordant and 193 discordant pairs. Proband-wise concordance was 0.20 in monozygotic and 0.13 in dizygotic pairs. Heritability was 0.27 overall, 0.83 in pairs diagnosed <= 50, and 0.19 in pairs diagnosed >50. High concordance in dizygotic twins suggests shared effects of early childhood environment. Ann Neurol 2019;85:600-605

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出版当年[2018]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学 1 区神经科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学 1 区神经科学

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出版当年[2017]版：

Q1 NEUROSCIENCES Q1 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 8.1 最新[2023版] 9.9 最新五年平均 10.25 出版当年[2017版] 10.748 出版当年五年平均 9.89 出版前一年[2016版] 9.496 出版后一年[2018版]

第一作者：

第一作者机构： [1]Division of Occupational and Environmental Medicine, University of California-San Francisco, San Francisco Veterans Affairs Health Care System, University of California–San Francisco, San Francisco, CA [*1]Division of Occupational and Environmental Medicine, University of California–San Francisco, 4150 Clement Street, Mailstop 127-P, San Francisco, CA 94121

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通讯机构： [*1]Division of Occupational and Environmental Medicine, University of California–San Francisco, 4150 Clement Street, Mailstop 127-P, San Francisco, CA 94121

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