机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.老年医学科[2]Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing Institute for Brain Disorders, China National Clinical Research Center for Geriatric Disorders, Beijing 100053, China.北京市老年保健及疾病防治中心北京市老年病医疗研究中心神经变性病教育部重点实验室脑功能疾病调控治疗北京市重点实验室
BackgroundPhysical frailty, characterized by reduced physiologic complexity and ability to cope with stressors, is closely associated with cognitive impairment, which increases the risk of poor clinical outcomes. To better capture the association between frailty and cognitive impairment, a new construct, cognitive frailty, has been proposed. Cognitive frailty is a clinical condition characterized by the simultaneous presence of physical frailty and cognitive impairment. There is little evidence on the relationship between physical frailty and cognition, as well as cognitive frailty, in Chinese older adults. We aimed to elucidate whether physical frailty is associated with cognitive impairment in an older Chinese population.MethodsData were obtained from the China Comprehensive Geriatric Assessment Study. The sample comprised 3202 community-dwelling adults, aged 60years and older, from seven Chinese cities. Physical frailty was assessed using a modified, four-item version of the Fried criteria, according to frailty phenotype. Cognitive function was assessed using the Mini-Mental State Examination (MMSE).ResultsThe prevalence of physical frailty, prefrailty, cognitive impairment, and cognitive frailty was 9.9, 33.9, 7.5, and 2.3%, respectively (weighted: 8.8, 33.8, 6.5, and 2.0%). The prevalence of the combination of prefrail/frail and cognitive impairment was 5.1% (weighted 4.5%). Frail participants performed worse on global cognition and all cognitive domains than robust and prefrail participants. The MMSE total score was positively correlated with walking speed and negatively correlated with age and frailty. A multivariate logistic regression revealed that after adjusting for age, gender, education level, living area, and chronic diseases, frailty, exhaustion, slowness, and inactivity were significantly associated with poor global cognition.ConclusionsThe standard prevalence of physical frailty, prefrailty, cognitive impairment, and cognitive frailty in community-dwelling older adults in China was 8.8, 33.8, 6.5, and 2.0%, respectively. Frailty, exhaustion, slowness, and inactivity were significantly associated with poor global cognition.
第一作者机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.[2]Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing Institute for Brain Disorders, China National Clinical Research Center for Geriatric Disorders, Beijing 100053, China.
通讯作者：
通讯机构：[2]Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing Institute for Brain Disorders, China National Clinical Research Center for Geriatric Disorders, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Ma Lina,Zhang Li,Sun Fei,et al.Cognitive function in Prefrail and frail community-dwelling older adults in China[J].BMC GERIATRICS.2019,19(1):53.doi:10.1186/s12877-019-1056-8.
APA：
Ma, Lina,Zhang, Li,Sun, Fei,Li, Yun&Tang, Zhe.(2019).Cognitive function in Prefrail and frail community-dwelling older adults in China.BMC GERIATRICS,19,(1)
MLA：
Ma, Lina,et al."Cognitive function in Prefrail and frail community-dwelling older adults in China".BMC GERIATRICS 19..1(2019):53
医学