机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院低氧适应转化医学北京市重点实验室[3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院
Objective To investigate the feasibility and safety of remote ischemic postconditioning (RIPC) in acute ischemic stroke patients after intravenous recombinant tissue plasminogen activator (rt-PA) thrombolysis (IVT). Methods We performed a pilot randomized trial involving acute ischemic stroke patients with IVT. The patients were randomized 1:1 to receive RIPC or standard medical therapy. In the RIPC group, the participants underwent instant RIPC within 2 h of IVT, followed by repeated RIPC therapy for 7 days. The feasibility end point was the completion of RIPC and time from the first RIPC to finishing IVT in the RIPC group. The safety end point included tissue and neurovascular injury resulting from RIPC, changes in vital signs, level of plasma myoglobin, any hemorrhagic transformation, and other adverse events. Results Thirty patients (15 RIPC and 15 Control) were recruited after IVT. The mean age was 65.7 +/- 10.2 years, with a National Institutes of Health Stroke Scale (NIHSS) score of 6.5 (4.0-10.0). The completion rate for RIPC was 97.0%. The mean time from first RIPC to completing IVT was 66.0 (25.0-75.0) min in the RIPC group. One case of hemorrhagic transformation was observed in the RIPC group. No significant difference was found in the level of myoglobin between the two groups (P > 0.05). Interpretation RIPC is effective and safe for AIS patients after intravenous rt-PA thrombolysis.
基金：
National Key R&D Program of China [2017YFC1308401]; Cheung Kong (Chang jiang) Scholars Program [T2014251]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201706]; Beijing Municipal Administration of Hospitals' Mission Plan [SML 20150802]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No 45, Changchun Street, Xicheng District, Beijing 100053, China[*2]Department of Neurology, Xuanwu Hospital, Capital Medical University, No 45, Changchun Street, Xicheng District, Beijing, China, 100053
推荐引用方式(GB/T 7714)：
Che Ruiwen,Zhao Wenbo,Ma Qingfeng,et al.rt-PA with remote ischemic postconditioning for acute ischemic stroke[J].ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY.2019,6(2):364-372.doi:10.1002/acn3.713.
APA：
Che, Ruiwen,Zhao, Wenbo,Ma, Qingfeng,Jiang, Fang,Wu, Longfei...&Ji, Xunming.(2019).rt-PA with remote ischemic postconditioning for acute ischemic stroke.ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY,6,(2)
MLA：
Che, Ruiwen,et al."rt-PA with remote ischemic postconditioning for acute ischemic stroke".ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 6..2(2019):364-372
