Objective. The authors recently used a combination of minimally invasive oblique lumbar interbody fusion (OLIF) and lateral fixation for the treatment of degenerative spine deformity. The early results were promising. Radiographic and clinical results as well as complications were retrospectively assessed in the current study. Methods. Eleven patients with degenerative spine deformity underwent combined OLIF and lateral instrumentation without real-time electromyography (EMG) monitoring. Radiographic measurements including coronal Cobb angle, central sacral vertebral line (CSVL), lumbar lordosis (LL), sagittal vertebral axis (SVA), pelvic tilt (PT), and LL-PI (pelvic incidence) mismatch were taken preoperatively and at last follow-up postoperatively in all patients. Concurrently, the visual analog score (VAS) for back pain and the Oswestry Disability Index (ODI) score were used to assess clinical outcomes. The fusion rate of OLIF cage, total blood loss, operation time, hospital stay, and complications were also evaluated. Results. At last follow-up, all patients who underwent combined OLIF and lateral instrumentation achieved statistically significant improvement in coronal Cobb angle (from 15.3 +/- 4.7 degrees to 5.9 +/- 3.1 degrees, p < 0.01), LL (from 34.3 +/- 9.0 degrees to 48.2 +/- 8.5 degrees, p < 0.01), PT (from 24.2 +/- 9.6 degrees to 16.2 +/- 6.0 degrees, p < 0.01), LL-PI mismatch (from 15.4 +/- 8.7 degrees to 7.0 +/- 3.7 degrees, p < 0.01), CSVL (from 2.1 +/- 2.2cm to 0.7 +/- 0.9cm, p = 0.01), and SVA (from 7.0 +/- 3.9cm to 2.9 +/- 1.8cm, p < 0.01). VAS for back pain (from 6.9 +/- 1.4 to 2.0 +/- 0.9, p < 0.05) and ODI (from 39.5 +/- 3.1 to 21.9 +/- 3.6, p < 0.01) improved significantly after surgery. Conclusions. A combination of OLIF and lateral instrumentation is an effective and safety means of achieving correction of both coronal and sagittal deformity, resulting in improvement of quality of life in patients with degenerative spine deformity. It is a promising way to treat patients with moderate degenerative spine deformity.