Objective: The aims of this study were to report brain characteristic abnormalities and to evaluate the relationship of blood-brain barrier (BBB) disruption and brain lesions in Chinese patients with NMOSD. Methods: Brain magnetic resonance imaging characteristics and cerebrospinal fluid (CSF) laboratory tests of 121 patients with NMOSD at acute attack were reviewed retrospectively. Qalb (CSF albumin/serum albumin) was used for assessment of disruption of BBB. Results: Brain MRI abnormalities were observed in 36.4% (44/121) of the NMOSD patients. Thirty patients (25%) showed typical-NMOSD abnormalities, including dorsal medulla lesions (n = 16, 13.2%), brainstem/cerebellum (n = 11, 9.1%), thalamus/hypothalamus (n = 3, 2.5%), periventricular while matter lesions (n = 4, 3.3%) hemispheric white matter (n = 4, 3.3%). Twenty-five patients (20.7%) had nonspecific lesions. Compared to the NMOSD patients without brain lesion, the proportion of patients who had abnormal BBB permeability was significantly higher in the abnormal brain MRI group (47.7% vs. 27.3%, P < 0.05). BBB permeability was not correlated to distribution of brain lesions or enhancement lesions. Qalb was associated with higher Expanded Disability Status Scale scores (r = 0.689, P < 0.05). Conclusions: Brain lesions are common in NMOSD patients. Marker of BBB permeability is associated with brain lesion and EDSS scores of NMOSD.
基金：
Beijing Municipal Administration of Hospitals Incubating Program [PX2019014]
第一作者机构：[a]Department of Neurology, Beijing Jishuitan Hospital, Xinjiekou No. 31 East Street, Xicheng District, Beijing 100035, China
通讯作者：
通讯机构：[a]Department of Neurology, Beijing Jishuitan Hospital, Xinjiekou No. 31 East Street, Xicheng District, Beijing 100035, China[b]Department of Neurology, XuanWu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
You Xiaofan,Yan Lirong,Li Xin,et al.Disruption of blood-brain barrier integrity associated with brain lesions in Chinese neuromyelitis optica spectrum disorder patients[J].MULTIPLE SCLEROSIS AND RELATED DISORDERS.2019,27:254-259.doi:10.1016/j.msard.2018.10.114.
APA：
You Xiaofan,Yan Lirong,Li Xin,Pang Ying,Guo Xiaolei...&Hu Hongtao.(2019).Disruption of blood-brain barrier integrity associated with brain lesions in Chinese neuromyelitis optica spectrum disorder patients.MULTIPLE SCLEROSIS AND RELATED DISORDERS,27,
MLA：
You Xiaofan,et al."Disruption of blood-brain barrier integrity associated with brain lesions in Chinese neuromyelitis optica spectrum disorder patients".MULTIPLE SCLEROSIS AND RELATED DISORDERS 27.(2019):254-259
