Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?
机构：[1]Department of Radiology, China-Japan Friendship Hospital, Beijing, China,[2]Graduate School of Peking Union Medical College, Beijing, China,[3]Department of Radiology, Fu Xing Hospital, Capital Medical University, Beijing, China,[4]Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, China,[5]Department of Imaging, Anhui Provincial Hospital, Hefei, China,[6]Department of Nuclear Medicine, Xuanwu Hospital, Beijing, China,首都医科大学宣武医院[7]Department of Science and Education, Shangluo Central Hospital, Shangluo, China
Purpose: Bell's palsy refers to acute idiopathic unilateral facial nerve palsy. It is a common disorder of the main motor pathway to the facial muscles. This study aimed to investigate the abnormal fraction amplitude of low frequency fluctuation (fALFF) of the brain in patients with early left and right Bell's palsy. Materials and Methods: Sixty-seven patients (left 33, right 34) and 37 age- and sex-matched healthy controls underwent resting-state functional magnetic resonance imaging (R-fMRI) examination. The fALFF values were measured from all subjects and were compared among the left palsy, right palsy, and control groups. Then, correlations between the Toronto Facial Grading System (TFGS) scores of the patients and the fALFF values of abnormal brain regions were analyzed. Results: Significant group differences in fALFF values among the three groups were observed mainly in the cerebral cortical, subcortical, and deep gray matter regions. Compared with the right Bell's palsy group, the left Bell's palsy group showed significantly decreased fALFF values in the left temporal pole of the superior temporal gyrus (TPOsup), right supramarginal, left and right middle cingulate cortex (MCC), left superior frontal gyrus (SFG), and left precentral gyrus (PreCG), and increased fALFF values were observed in the right SFG and PreCG. Furthermore, altered fALFF values correlated positively with the TFGS scores in the left superior TPO, bilateral MCC, and right PreCG, and correlated negatively with the TFGS scores in the right SFG of the left Bell's palsy group. Altered fALFF values correlated positively with the TFGS scores in the bilateral MCC and right PreCG and correlated negatively with the TFGS scores in the left superior TPO and SFG of the right Bell's palsy group. Conclusion: Regulatory mechanisms seem to differ between patients with left and right early Bell's palsy. The severity of the disease is associated with these functional alterations.
基金：
This study was supported by the grants from National
Natural Science Foundation of China (NSFC) (Nos. 81571641,
81628008, and 81771824), and The National Key Research
and Development Program of China (Nos. 2016YFC0100105,
2016YFC0103003, and 2016YFC1307001).
第一作者机构：[1]Department of Radiology, China-Japan Friendship Hospital, Beijing, China,[2]Graduate School of Peking Union Medical College, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology, China-Japan Friendship Hospital, Beijing, China,
推荐引用方式(GB/T 7714)：
Xiaowei Han,Haimei Li,Xiaochun Wang,et al.Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?[J].FRONTIERS IN NEUROSCIENCE.2018,12(NOV):797.doi:10.3389/fnins.2018.00797.
APA：
Xiaowei Han,Haimei Li,Xiaochun Wang,Yijiang Zhu,Tianbin Song...&Guolin Ma.(2018).Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?.FRONTIERS IN NEUROSCIENCE,12,(NOV)
MLA：
Xiaowei Han,et al."Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?".FRONTIERS IN NEUROSCIENCE 12..NOV(2018):797
