机构：[1]Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China[2]Department of Microbiology, School of Basic Medical Science, Capital Medical University, Beijing 100069, China[3]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经外科首都医科大学宣武医院[4]Beijing Key Laboratory of Epilepsy, Beijing 100093, China[5]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China
Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively. In contrast, no detectable EBV and HHV6 antigen expression was found in brain tissues of the control group. The co-expression of EBV and HHV6 was detected in 20.0% (6/30) of individuals. In particular, a 4-year-old boy had a typical clinical course, including a medical history of viral encephalitis, intractable epilepsy, and hemispheric atrophy. The co-expression of EBV and HHV6 was detected in neurons and astrocytes in the brain tissue, accompanied by a high frequency of CD8(+) T cells. Our results suggest that EBV and HHV6 infection and the activation of CD8(+) T cells are involved in the pathogenesis of RE.
基金：
This work was supported by the National Natural
Science Foundation of China (81701992, 81471957, and 81671971),
the Beijing Municipal Natural Science Foundation (7144217), the
Capital Applied Clinic Research Programs of Science and Technology
(Z131107002213171), the Beijing Rising-star Plan of Science
and Technology (Z141107001814042), and Scientific Research
Common Program of Beijing Municipal Commission of Education
(KM201610025001)
第一作者机构：[1]Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China
通讯作者：
通讯机构：[1]Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China[2]Department of Microbiology, School of Basic Medical Science, Capital Medical University, Beijing 100069, China[4]Beijing Key Laboratory of Epilepsy, Beijing 100093, China[5]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China
推荐引用方式(GB/T 7714)：
Dong Liu,Xin Wang,Yisong Wang,et al.Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis[J].VIROLOGICA SINICA.2018,33(5):402-409.doi:10.1007/s12250-018-0063-9.
APA：
Dong Liu,Xin Wang,Yisong Wang,Peigang Wang,Dongying Fan...&Guoming Luan.(2018).Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis.VIROLOGICA SINICA,33,(5)
MLA：
Dong Liu,et al."Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis".VIROLOGICA SINICA 33..5(2018):402-409
