Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: A randomized, double-blind, sham-controlled pilot study
机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[b]Beijing Key Laboratory of Neuromodulation, Beijing, China[c]Department of Neurology, Beijing Shunyi Hospital, Beijing, China[d]Department of Neurology, Massachusetts General Hospital, Boston, MA, USA[e]Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
Background: Repetitive transcranial magnetic stimulation (rTMS) has been considered to be a promising technique for the treatment of neuropsychiatric disorders. However, little is known about the effectiveness of rTMS in the treatment of generalized anxiety disorder (GAD). Moreover, treatment data on comorbid GAD and insomnia remain lacking. The aim of this study was to examine the therapeutic effects of 1 Hz rTMS applied over the right parietal lobe on both anxiety and insomnia symptoms in patients with comorbid GAD and insomnia. Methods: 36 patients were randomized to either sham or active rTMS group (n = 18 each group). The rTMS was administered over the right posterior parietal cortex (P4 electrode site) at a frequency of 1 Hz and an intensity of 90% of the resting motor threshold. Results: Ten days of 1 Hz rTMS to the right parietal lobe significantly improved both anxiety and insomnia symptoms in the active group. Although the anxiety severity was not significantly correlated with insomnia severity at baseline, the improvement in the Hamilton Rating Scale for Anxiety (HRSA) scores were positively correlated with improvement in the Pittsburgh Sleep Quality Index (PSQI) scores. Conclusions: The present study is the first randomized sham-controlled study to assess the effectiveness of low frequency rTMS on the right parietal lobe in patients with comorbid GAD and insomnia. Our results suggested that 1 Hz low frequency rTMS administered over the parietal cortex is effective for both anxiety and insomnia symptoms in patients with comorbid GAD and insomnia. (C) 2018 Elsevier Inc. All rights reserved.
基金：
the Natural Science Foundation of China, (Grant No. 81301138, 81271494),
the Beijing Municipal Administration of Hospitals, (Grant No. QML20150802),
the National High-Tech R&D Program of China (863 Program),(Grant No. 2015AA020514).
第一作者机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Beijing Key Laboratory of Neuromodulation, Beijing, China[d]Department of Neurology, Massachusetts General Hospital, Boston, MA, USA[e]Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053,China
推荐引用方式(GB/T 7714)：
Zhaoyang Huang,Yue Li,Matt T. Bianchi,et al.Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: A randomized, double-blind, sham-controlled pilot study[J].BRAIN STIMULATION.2018,11(5):1103-1109.doi:10.1016/j.brs.2018.05.016.
APA：
Zhaoyang Huang,Yue Li,Matt T. Bianchi,Shuqin Zhan,Fengying Jiang...&Yuping Wang.(2018).Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: A randomized, double-blind, sham-controlled pilot study.BRAIN STIMULATION,11,(5)
MLA：
Zhaoyang Huang,et al."Repetitive transcranial magnetic stimulation of the right parietal cortex for comorbid generalized anxiety disorder and insomnia: A randomized, double-blind, sham-controlled pilot study".BRAIN STIMULATION 11..5(2018):1103-1109
医学