机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street , Xicheng District, Beijing 100053, China.神经外科首都医科大学宣武医院[2]Human Motor Control Section, Medical Neurology Branch, NINDS, NIH, Bethesda, MD, USA.[3]Center of Parkinson’s disease, Beijing Institute for Brain Disorders, Beijing, China.[4]Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, Beijing, China.
Background: The cardinal features of Parkinson's disease (PD) are bradykinesia, rigidity and rest tremor. Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms. This study aims to characterize properties of oscillatory activity in the basal ganglia and motor thalamus in patients with PD. Methods: Twenty-nine patients with PD who underwent bilateral or unilateral electrode implantation for subthalamic nucleus (STN) DBS (n = 11), unilateral pallidotomy (n = 9) and unilateral thalamotomy (n = 9) were studied. Microelectrode recordings in the STN, globus pallidus internus (GPi) and ventral oral posterior/ventral intermediate of thalamus (Vop/Vim) were performed. Electromyography of the contralateral limbs was recorded. Single unit characteristics including interspike intervals were analyzed. Spectral and coherence analyses were assessed. Mean spontaneous firing rate (MSFR) of neurons was calculated. Analysis of variance and X-2 test were performed. Results: Of 76 STN neurons, 39.5% were 4-6 Hz band oscillatory neurons and 28.9% were beta frequency band (beta FB) oscillatory neurons. The MSFR was 44.2 +/- 7.6 Hz. Of 62 GPi neurons, 37.1% were 4-6 Hz band oscillatory neurons and 27. 4% were beta FB neurons. The MSFR was 80.9 +/- 9.6 Hz. Of 44 Vop neurons, 65.9% were 4-6 Hz band oscillatory neurons and 9% were beta FB neurons. The MSFR was 24.4 +/- 4.2 Hz. Of 30 Vim oscillatory neurons, 70% were 4-6 Hz band oscillatory neurons and 13.3% were beta FB neurons. The MSFR was 30.3 +/- 3.6 Hz. Further analysis indicated that proportion of beta FB oscillatory neurons in STN and GPi was higher than that of similar neurons in the Vop and Vim (P < 0.05). Conversely, the proportion of 4-6 Hz band oscillatory neurons and tremor related neurons in the Vim and Vop was higher than that of STN and GPi (P < 0.05). The highest MSFR was for GPi oscillatory neurons whereas the lowest MSFR was for Vop oscillatory neurons (P < 0.005). Conclusion: The alterations in neuronal activity in basal ganglia play a critical role in generation of parkinsonism. beta oscillatory activity is more prominent in basal ganglia than in thalamus suggesting that the activity likely results from dopaminergic depletion. While both basal ganglia and thalamus have tremor activity, the thalamus appears to play a more important role in tremor production, and basal ganglia beta oscillatory activity might be the trigger.
基金：
National Natural Science Foundation of China, Ministry of Education of Republic of China, Seed Grant of International Alliance of Translational Neuroscience; Intramural Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
第一作者机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street , Xicheng District, Beijing 100053, China.
通讯作者：
通讯机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street , Xicheng District, Beijing 100053, China.[3]Center of Parkinson’s disease, Beijing Institute for Brain Disorders, Beijing, China.[4]Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, Beijing, China.
推荐引用方式(GB/T 7714)：
G. Du,P. Zhuang,M. Hallett,et al.Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson's disease[J].TRANSLATIONAL NEURODEGENERATION.2018,7:doi:10.1186/s40035-018-0123-y.
APA：
G. Du,P. Zhuang,M. Hallett,Y.-Q. Zhang,J.-Y. Li&Y.-J. Li.(2018).Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson's disease.TRANSLATIONAL NEURODEGENERATION,7,
MLA：
G. Du,et al."Properties of oscillatory neuronal activity in the basal ganglia and thalamus in patients with Parkinson's disease".TRANSLATIONAL NEURODEGENERATION 7.(2018)
