机构：[1]Departments of Radiology,Xuanwu Hospital, Capital Medical University, Beijing, P.R. China放射科首都医科大学宣武医院[2]Departments of Neurology,Xuanwu Hospital, Capital Medical University, Beijing, P.R. China神经内科首都医科大学宣武医院[3]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China[4]Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, P.R. China[5]State Key Laboratory of Cognitive Neuroscience and Learning and International Data Group/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China[6]Beijing Key Lab of MRI and Brain Informatics, Beijing, P.R. China.磁共振成像脑信息学北京市重点实验室首都医科大学宣武医院
BACKGROUND AND PURPOSE: Anti-N-methyl-D-aspertate receptor encephalitis is an autoimmune-mediated disease without specific brain MRI features. Our aim was to investigate the brain MR imaging characteristics of anti-N-methyl-D-aspartate receptor encephalitis and their associations with clinical outcome at a 2-year follow-up. MATERIALS AND METHODS: We enrolled 53 patients with anti-N-methyl-D-aspartate receptor encephalitis and performed 2-year follow-up. Brain MRIs were acquired for all patients at the onset phase. The brain MR imaging manifestations were classified into 4 types: type 1: normal MR imaging findings; type 2: only hippocampal lesions; type 3: lesions not involving the hippocampus; and type 4: lesions in both the hippocampus and other brain areas. The modified Rankin Scale score at 2-year follow-up was assessed, and the association between the mRS and onset brain MR imaging characteristics was evaluated. RESULTS: Twenty-eight (28/53, 53%) patients had normal MR imaging findings (type 1), and the others (25/53, 47%) had abnormal MRI findings: type 2: 7 patients (13%); type 3: seven patients (13%); and type 4: eleven patients (21%). Normal brain MRI findings were more common in female patients (P = .02). Psychiatric and behavioral abnormalities were more common in adults (P = .015), and autonomic symptoms (P = .025) were more common in pediatric patients. The presence of hippocampal lesions (P = .008, OR = 9.584; 95% CI, 1.803-50.931) and relapse (P = .043, OR = 0.111; 95% CI, 0.013-0.930) was associated with poor outcome. CONCLUSIONS: Normal brain MRI findings were observed in half of the patients. Lesions in the hippocampus were the most common MR imaging abnormal finding. The presence of hippocampal lesions is the main MR imaging predictor for poor prognosis in patients with anti-N-methyl-D-aspartate receptor encephalitis.
基金：
the European Committee for Treatment and Research in Multiple Sclerosis–Magnetic Imaging in Multiple Sclerosis (ECTRIMS-MAGNMIS)
Fellowship from ECTRIMS (Y.L.);
the National Science Foundation of China (Nos. 81101038, 81401377, 81471221. and 81230028);
the National Basic Research Program of China (2013CB966900);
the Beijing Natural Science Fund (No. 7133244);
the Beijing Nova Programme (xx2013045);
the Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support (code: ZYLX201609);
Key Projects in the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period (2012BAI10B04).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区核医学3 区临床神经病学3 区神经成像
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
JCR分区：
出版当年[2016]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROIMAGINGQ2CLINICAL NEUROLOGY
最新[2023]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2CLINICAL NEUROLOGYQ2NEUROIMAGING
第一作者机构：[1]Departments of Radiology,Xuanwu Hospital, Capital Medical University, Beijing, P.R. China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[*2]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[*3]Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China
推荐引用方式(GB/T 7714)：
T. Zhang ,Y. Duan ,J. Ye ,et al.Brain MRI Characteristics of Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Their Associations with 2-Year Clinical Outcome[J].AMERICAN JOURNAL OF NEURORADIOLOGY.2018,39(5):824-829.doi:10.3174/ajnr.A5593.
APA：
T. Zhang,,Y. Duan,,J. Ye,,W. Xu,,N. Shu,...&Y. Liu.(2018).Brain MRI Characteristics of Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Their Associations with 2-Year Clinical Outcome.AMERICAN JOURNAL OF NEURORADIOLOGY,39,(5)
MLA：
T. Zhang,,et al."Brain MRI Characteristics of Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Their Associations with 2-Year Clinical Outcome".AMERICAN JOURNAL OF NEURORADIOLOGY 39..5(2018):824-829
