机构：[1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.[2]Lifespan Connectomics and Behavior Team, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.[3]Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA.[4]Department of Psychology, University of Chinese Academy of Sciences, Shijingshan, Beijing, 100049, China.[5]Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China.[6]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China.神经内科首都医科大学宣武医院[7]Center of Alzheimer’s Disease, Beijing, Institute for Brain Disorders, Beijing, 100053, China.[8]Beijing Institute of Geriatrics, Beijing, 100053, China.[9]National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.[10]PKU Care Rehabilitation Hospital, Beijing, 100053, China.
The progression of Alzheimer's Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.
基金：
the National Natural Science Foundation of China (11674388, 11204369),
the Startup Foundation for Young Talents of the Institute of Psychology (Y1CX222005),
the National Key Basic Research and Development (973) Program (2015CB351702)
the National Natural Science Foundation of China (81471740).
the National Key Research and Development Program of China (2016YFC1306300),
National Natural Science Foundation of China (Grant No. 31371007, 81430037, 61633018),
Beijing Nature Science Foundation (7161009),
Beijing Municipal Science & Technology Commission (Z161100002616020),
Fundamental and Clinical Cooperative Research Program of Capital Medical University (16JL-L08)
第一作者机构：[1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.[2]Lifespan Connectomics and Behavior Team, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.[3]Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA.
通讯作者：
通讯机构：[1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.[2]Lifespan Connectomics and Behavior Team, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.[3]Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA.[6]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China.[7]Center of Alzheimer’s Disease, Beijing, Institute for Brain Disorders, Beijing, 100053, China.[8]Beijing Institute of Geriatrics, Beijing, 100053, China.[9]National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.[10]PKU Care Rehabilitation Hospital, Beijing, 100053, China.
推荐引用方式(GB/T 7714)：
Lili Jiang,Danyang Sui,Kaini Qiao,et al.Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression[J].SCIENTIFIC REPORTS.2018,8(1):1324.doi:10.1038/s41598-018-19674-7.
APA：
Lili Jiang,Danyang Sui,Kaini Qiao,Hao-Ming Dong,Luonan Chen&Ying Han.(2018).Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression.SCIENTIFIC REPORTS,8,(1)
MLA：
Lili Jiang,et al."Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression".SCIENTIFIC REPORTS 8..1(2018):1324
