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Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3 beta pathway in cells and in APP/PS1 transgenic mice

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文献详情

资源类型：
WOS体系：

收录情况： ◇ SCIE

作者：
Xiaomin Yin [a,b] * ; Chen Chen [a] ; Ting Xu [b] ; Lin Li [a] ; Lan Zhang [a] ;
机构： [a]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China [b]Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, Jiangsu 226001, PR China
出处：
DOI： 10.1016/j.bbrc.2017.11.059
ISSN：

关键词： Tetrahydroxystilbene glucoside Amyloid precursor protein Glycogen synthase kinase-3 beta Alzheimer's disease

摘要：
Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (A beta) production. Here, we determined the effect of Tetrahydroxystilbene glucoside (TSG) on the AICT-GSK3 beta pathway. We found GSK3 beta increased APP-KPI inclusion level and interacted with the splicing factor ASF. TSG was intragastrically administered to 5-month-old APP/PS1 transgenic mice for 12 months. We found that the activated the AKT-GSK3 beta signaling pathway suppressed APP-KPI inclusion. Moreover, TSG treatment attenuated amyloid deposition in APP/PS1 mice. This study demonstrates the neuroprotective effect of TSG on APP expression, suggesting that TSG may be beneficial for AD prevention and treatment. (C) 2017 Elsevier Inc. All rights reserved.

基金：
the National Natural Science Foundation of China (Nos. 81503077, 81273498, 81473373), National Science and Technology Major Project for NewDrug Research and Development of China (No. 2015ZX09101-016).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2016]版：
Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [a]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China [b]Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, Jiangsu 226001, PR China
通讯作者：
通讯机构： [a]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Xiaomin Yin,Chen Chen,Ting Xu,et al.Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3 beta pathway in cells and in APP/PS1 transgenic mice[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,495(1):672-678.doi:10.1016/j.bbrc.2017.11.059.
APA：
Xiaomin Yin,Chen Chen,Ting Xu,Lin Li&Lan Zhang.(2018).Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3 beta pathway in cells and in APP/PS1 transgenic mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,495,(1)
MLA：
Xiaomin Yin,et al."Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3 beta pathway in cells and in APP/PS1 transgenic mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 495..1(2018):672-678

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