机构：[1]Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School,Charlestown, Massachusetts[2]Departments of Critical Care Medicine, Neurology and Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania[3]Department of Neurology, Cardio-Neurology Clinic, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts[4]Cerebrovascular Research Center, XuanWu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
OBJECTIVE Acute central nervous system (CNS) injury after stroke and trauma remains a clinical challenge with limited diagnostic and therapeutic approaches. In this article, we review studies suggesting that after CNS injury, mitochondria can be released into extracellular space as a "help-me" signal to augment recovery. Results are taken from experimental studies in cell and animal models and an initial proof-of-concept analysis in humans suggesting the functional relevance of extracellular mitochondria after acute CNS injury. OBSERVATIONS After acute CNS injury, (1) mitochondria may be released into extracellular space, (2) mitochondria may be transferred between cells, and (3) levels of extracellular mitochondria may serve as potential biomarkers for recovery. CONCLUSIONS AND RELEVANCE Further translational and clinical studies are warranted to assess the overall hypothesis of using extracellular mitochondria as a therapy and biomarker in the CNS after stroke and trauma.
基金：
the National Institutes of Health and the Rappaport Foundation.
第一作者机构：[1]Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School,Charlestown, Massachusetts[*1]Neuroprotection Research Laboratories, Harvard Medical School, Massachusetts General Hospital, East 149-2401, Charlestown, MA 02129
通讯作者：
通讯机构：[*1]Neuroprotection Research Laboratories, Harvard Medical School, Massachusetts General Hospital, East 149-2401, Charlestown, MA 02129
推荐引用方式(GB/T 7714)：
Kazuhide Hayakawa,Morgan Bruzzese,Sherry H-Y. Chou ,et al.Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury[J].JAMA NEUROLOGY.2018,75(1):119-122.doi:10.1001/jamaneurol.2017.3475.
APA：
Kazuhide Hayakawa,Morgan Bruzzese,Sherry H-Y. Chou,,MingMing Ning,,Xunming Ji,&Eng H. Lo,.(2018).Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury.JAMA NEUROLOGY,75,(1)
MLA：
Kazuhide Hayakawa,et al."Extracellular Mitochondria for Therapy and Diagnosis in Acute Central Nervous System Injury".JAMA NEUROLOGY 75..1(2018):119-122
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