机构：[1]Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院循证医学中心[2]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China血管超声科首都医科大学宣武医院[3]Department of Applied Mathematics, School of Mathematics and System Science, Beihang University, Beijing, China[4]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China老年医学科首都医科大学宣武医院[5]Department of Geriatrics, Youyi Hospital, Capital Medical University, Beijing, China[6]Department of Neurological, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院神经外科[7]Department of Neurological Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院神经外科
We explored the associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid atherosclerosis with all phenotypes and cardiovascular disease (CVD) events in Chinese older adults. A total of 1257 adults aged 55 years who were free of CVD were enrolled in this cohort study. Lipoprotein-associated phospholipase A2 level was evaluated in 3 categories: Lp-PLA2 < 175, 175 Lp-PLA2 < 223, and Lp-PLA2 223 ng/mL. The highest level of Lp-PLA2 was independently associated with common carotid artery intima-media thickening (1.0 mm; odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.14-2.26) and carotid plaque (OR: 1.42, 95% CI: 1.01-1.99) in individuals without carotid artery stenosis. At the end of the 5-year follow-up, after adjustment for CVD risk factors and carotid atherosclerosis status, Lp-PLA2 had remained an independent predictor for myocardial infarction (MI; hazard ratio [HR]: 1.90, 95% CI: 1.02-3.55) and CVD death (HR: 1.78, 95% CI: 1.02-3.13). However, no association was found with stroke. Therefore, elevated Lp-PLA2 level in the older adults studied was associated with an increased risk of carotid atherosclerosis and MI and CVD mortality. Lipoprotein-associated phospholipase A2 assessment might be used for MI and CVD death risk prediction.
基金：
the Commission of Science and Technology of Beijing (Grant No: D121100004912002),
Beijing Natural Science Foundation (Grant No: 7152068),
Xuanwu Hospital, Capital Medical University, Beijing, China.
第一作者机构：[1]Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurological Surgery, Xuanwu Hospital, Capital Medical University, No 45 Changchun street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Chunxiu Wang ,Xianghua Fang ,Yang Hua ,et al.Lipoprotein-Associated Phospholipase A2 and Risk of Carotid Atherosclerosis and Cardiovascular Events in Community-Based Older Adults in China[J].ANGIOLOGY.2018,69(1):49-58.doi:10.1177/0003319717704554.
APA：
Chunxiu Wang,,Xianghua Fang,,Yang Hua,,Yutong Liu,,Zhongying Zhang,...&Xunming Ji,.(2018).Lipoprotein-Associated Phospholipase A2 and Risk of Carotid Atherosclerosis and Cardiovascular Events in Community-Based Older Adults in China.ANGIOLOGY,69,(1)
MLA：
Chunxiu Wang,,et al."Lipoprotein-Associated Phospholipase A2 and Risk of Carotid Atherosclerosis and Cardiovascular Events in Community-Based Older Adults in China".ANGIOLOGY 69..1(2018):49-58
