机构：[1]Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.神经内科老年医学科首都医科大学宣武医院[2]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.放射科首都医科大学宣武医院[3]Beijing Key Laboratory of MRI and Brain Informatics, Beijing, 100053, China.[4]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing, 100053, China.[5]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Beijing, 100053, China.[6]National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.
Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.
基金：
the Beijing Municipal government (PXM2017_026283_000002),
Beijing Municipal Science & Technology Commission (Z161100005116011; Z171100000117013),
Beijing Municipal Administration of Hospitals’ Mission Plan (SML20150803),
National Natural Science Foundation of China (61473196),
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding (ZYLX201609),
Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2012BAI10B04).
第一作者机构：[1]Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.
通讯作者：
通讯机构：[1]Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.[4]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing, 100053, China.[5]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Beijing, 100053, China.[6]National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.
推荐引用方式(GB/T 7714)：
Tao-Mian Mi,Shan-Shan Mei,Pei-Peng Liang,et al.Altered resting-state brain activity in Parkinson's disease patients with freezing of gait[J].SCIENTIFIC REPORTS.2017,7(1):16711.doi:10.1038/s41598-017-16922-0.
APA：
Tao-Mian Mi,Shan-Shan Mei,Pei-Peng Liang,Lin-Lin Gao,Kun-Cheng Li...&Piu Chan.(2017).Altered resting-state brain activity in Parkinson's disease patients with freezing of gait.SCIENTIFIC REPORTS,7,(1)
MLA：
Tao-Mian Mi,et al."Altered resting-state brain activity in Parkinson's disease patients with freezing of gait".SCIENTIFIC REPORTS 7..1(2017):16711
