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Gliosarcomas with the BRAF V600E mutation: a report of two cases and review of the literature

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收录情况： ◇ SCIE

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机构： [1]Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing, China [2]Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China [3]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China

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Gliosarcoma, which is regarded as a variant of glioblastoma, is a rare malignant neoplasm of the central nervous system. Both its sarcomatous component and glial component are reported to share significant clinical and genetic similarities. However, gliosarcomas are considered to be characterised by a lack of the BRAF V600E mutation. Here, we report two cases of gliosarcoma harbouring the BRAF V600E mutation, of which one case appears to have arisen de novo, while the other likely arose from ganglioglioma. Interestingly, the BRAF V600E mutation was detected only in the glial component in the first case, but was present in both the glial and the sarcomatous components in the recurrent gliosarcoma. Furthermore, the different mutation state of BRAF V600E in our two cases suggests that the malignant transformation of gliosarcoma might have different underlying genetic alterations and mechanisms in de novo versus recurrent gliosarcoma.

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出版当年[2016]版：

大类 | 3 区医学

小类 | 2 区病理学

最新[2023]版：

大类 | 4 区医学

小类 | 3 区病理学

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出版当年[2015]版：

Q2 PATHOLOGY

最新[2023]版：

Q2 PATHOLOGY

影响因子： 2.5 最新[2023版] 2.8 最新五年平均 2.912 出版当年[2015版] 2.623 出版当年五年平均 2.915 出版前一年[2014版] 2.687 出版后一年[2016版]

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第一作者机构： [1]Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing, China

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通讯机构： [*1]Department of Pathology, xuanwu hospital, Beijing, China

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