机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[2]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[3]Department of Radiology, Beijing Chuiyangliu Hospital, Beijing, 100022, China.[4]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[5]Department of Physiology, Capital Medical University, Beijing, 100069, China.[6]Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.[7]Department of Neurology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.神经内科首都医科大学宣武医院[8]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[9]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China.[10]Beijing Key Laboratory on Parkinson’s Disease, Beijing, 100053, China.[11]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China.
Parkinson disease (PD) is associated with multiple factors, including iron, which is demonstrated to deposit excessively in PD brains. We detected iron deposition by susceptibility weighted image (SWI) and measured the levels of iron metabolism-related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum of PD patients and control subjects. Clinical symptoms of PD were evaluated by series of rating scales. Relationships among above factors were analyzed. Results showed that corrected phase (CP) value of substantia nigra (SN) was significantly decreased in PD group compared to control group, hence, SN was the main region with excessive iron deposition. In PD group, ferritin was significantly elevated in CSF and reduced in serum compared to control group, and levels of ferritin in CSF and serum were both significantly and positively correlated with CP value of SN, thus, abnormal iron metabolism in central and peripheral systems was associated with iron deposition. CP value of SN in PD group was significantly and negatively correlated with interleukin-1 beta level in CSF, so interleukin-1 beta might be a neuroinflammatory factor produced by excessive iron in SN. Iron deposition in SN was significantly correlated with motor symptoms and part of non-motor symptoms of PD.
基金：
The National Key Research and Development Program of China (2016YFC1306000, 2016YFC1306300),
The National Natural Science Foundation of China (81571229, 81071015, 30770745),
The Key Project of National Natural Science Foundation of China (81030062),
The Key Project of Natural Science Foundation of Beijing, China (B) (kz201610025030),
The Key Project of Natural Science Foundation of Beijing, China (4161004, kz200910025001),
The Natural Science Foundation of Beijing, China (7082032),
National Key Basic Research Program of China (2011CB504100),
Important National Science & Technology Specific Projects (2011ZX09102-003-01),
National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03),
Project of Beijing Institute for Brain Disorders (BIBDPXM2013_014226_07_000084,
High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26),
Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514),
Capital Clinical Characteristic Application Research (Z12110700100000, Z121107001012161),
Beijing Healthcare Research Project, China (JING-15-2, JING-15-3),
Excellent Personnel Training Project of Beijing, China (20071D0300400076, 2016000021469G209),
Basic-Clinical Research Cooperation Funding of Capital Medical University, China (2015-JL-PT-X04, 10JL49, 14JL15),
Youth Research Funding, Beijing Tiantan Hospital, Capital Medical University, China (2014-YQN-YS-18, 2015-YQN-15, 2015-YQN-05, 2015-YQN-14, 2015-YQN-17).
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[4]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.[8]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.[9]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China.[10]Beijing Key Laboratory on Parkinson’s Disease, Beijing, 100053, China.[11]Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China.
推荐引用方式(GB/T 7714)：
Zhuo Liu,Hui-cong Shen,Teng-hong Lian,et al.Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance[J].SCIENTIFIC REPORTS.2017,7(1):14973.doi:10.1038/s41598-017-14721-1.
APA：
Zhuo Liu,Hui-cong Shen,Teng-hong Lian,Lei Mao,Shou-xian Tang...&Wei Zhang.(2017).Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance.SCIENTIFIC REPORTS,7,(1)
MLA：
Zhuo Liu,et al."Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance".SCIENTIFIC REPORTS 7..1(2017):14973
